Evidence map›Paper›PMID 40281065›Full record

ArticleScientific reports2025

Associations of healthy lifestyle and accelerated aging with incident breast cancer in pre- and postmenopausal women: a population-based cohort study.

Wenyi Liu, Mengqing Yan, Zhixing Fan, Zhongli Ma, Yuanhang Zhu, Hui Chang, Ruoxin Jiang, Chenchen Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenyi Liu *The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China.
Mengqing Yan *Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Zhixing FanDepartment of Cardiology, The First College of Clinical Medical Science, China Three Gorges University and Yichang Central People's Hospital, Yichang, 443003, Hubei, China.
Zhongli MaThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China.
Yuanhang ZhuThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China.
Hui ChangThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China.
Ruoxin JiangThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China.
Chenchen RenThe Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450001, Henan, China. renchenchen1106@126.com.

Funding

National Natural Science Foundation of China 82371597
6 · The paper itself

Abstract

Breast cancer is one of the most common malignancies in women. This study aimed to explore the association between healthy lifestyle, biological aging and breast cancer risk in pre- and postmenopausal women. This study included 125,579 participants. Biological aging was calculated using the PhenoAge algorithm. Cox regression models and counterfactual mediation analysis was utilized. During an average follow-up of 13.65 years, 5418 breast cancers occurred. In the overall women participants, compared to the healthy lifestyle group, the HR (95% CI) for unhealthy lifestyle regarding incident breast cancer was 1.28 (1.13, 1.33). Compared to the lowest tertile of accelerated aging (AA), the HR (95% CI) for the highest tertile regarding breast cancer risk was 1.22 (1.14, 1.30). Consistent results observed only in postmenopausal participants. The joint effect of a healthy lifestyle and AA on breast cancer risk was statistically significant (P < 0.001). The AA-mediated breast cancer risk ratio was 17.69 (95% CI 8.19, 27.19) when comparing healthy to unhealthy lifestyles. In the study, healthy lifestyle and lower levels of AA were significantly associated with a reduced risk of breast cancer, particularly among postmenopausal women. In addition, AA mediated 17.02-17.69% of the link between lifestyle and breast cancer risk.

Indexed as

AgingBreast NeoplasmsHealthy LifestylePostmenopausePremenopauseAdultAgedCohort StudiesFemaleHumansIncidenceLife StyleMiddle AgedRisk FactorsAccelerated biological agingBreast cancerCohort studyCounterfactual mediation analysisHealthy lifestyle

Identifiers

PMID40281065
PMCPMC12032409

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.