Evidence map›Paper›PMID 40280886›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025

Effectiveness of the Bedaquiline, Pretomanid, and Linezolid Regimen, With or Without Moxifloxacin, for Drug-Resistant Tuberculosis in Ukraine Under Programmatic Conditions.

Victor Naestholt Dahl, Ole Skouvig Pedersen, Tetiana Butova, Mykhailo Kuzhko, Olena Raznatovska, Andrii Fedorec, Vitalii Vekshyn, Valentyna Hlynenko, Nataliia Yevsiukova, Leonid Hryshchuk and 15 more

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Victor Naestholt DahlDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0003-2965-6348
Ole Skouvig PedersenDepartment of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.ORCID 0009-0002-7338-1433
Tetiana ButovaOutpatient Department, Merefa Central District Hospital, Merefa, Ukraine.ORCID 0000-0001-6587-222X
Mykhailo KuzhkoDepartment of Chemoresistant Tuberculosis, National Institute of Phthisiology and Pulmonology Named After F. G. Yanovskyi NAMS of Ukraine, Kyiv, Ukraine.
Olena RaznatovskaDepartment of Phthisiology and Pulmonology, Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine.ORCID 0000-0003-2252-9063
Andrii FedorecThe Pulmonary Tuberculosis Department No. 2, Zaporizhzhia Regional Phthisiology and Pulmonology Clinical Treatment and Diagnostic Center, Zaporizhzhia, Ukraine.
Vitalii VekshynDepartment of Infectious Diseases, Childhood Infections and Phthisiology, Kharkiv National Medical University, Kharkiv, Ukraine.ORCID 0000-0003-2834-8773
Valentyna HlynenkoOutpatient Department, Sumy Regional Clinical Anti-tuberculosis Dispensary, Sumy, Ukraine.
Nataliia YevsiukovaOutpatient Department, Sumy Regional Clinical Anti-tuberculosis Dispensary, Sumy, Ukraine.
Leonid HryshchukDepartment of Internal Medicine Propedeutics and Phthisiology, Ternopil National Medical University, Ternopil, Ukraine.ORCID 0000-0002-2528-8843
Svitlana KornahaDepartment of Internal Medicine Propedeutics and Phthisiology, Ternopil National Medical University, Ternopil, Ukraine.
Nataliia ChursinaDepartment of Internal and Family Medicine, Lesya Ukrainka Volyn National University, Lutsk, Ukraine.
Natalia KondratyukDepartment of Histology and Medical Biology, Lesya Ukrainka Volyn National University, Lutsk, Ukraine.
Lyubov MarkovtsiyTuberculosis Department, Center of Pulmonary Diseases, Uzhhoro, Ukraine.
Vasyl SkrypTuberculosis Department, Center of Pulmonary Diseases, Uzhhoro, Ukraine.
Artemii BogomolovDepartment of Phthisiology with Clinical Immunology and Allergology, National Pirogov Memorial Medical University, Vinnytsya, Ukraine.ORCID 0000-0002-5336-4858
Tetiana KlymenkoConsultative and Diagnostic Department, Regional Phthisiopulmonology Center, Vinnytsya, Ukraine.
Daria YankovskaDepartment of Infectious Diseases, Childhood Infections and Phthisiology, Kharkiv National Medical University, Kharkiv, Ukraine.ORCID 0009-0002-2538-4867
Mykola OstrovskyyDepartment Phthisiology and Pulmonology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.ORCID 0000-0002-3922-0583
Iryna MakoidaDepartment Phthisiology and Pulmonology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.ORCID 0000-0002-8258-2643
Daria LevandovskaCherkasy Regional Tuberculosis Dispensary, Cherkasy, Ukraine.
Yuulia ShpakCherkasy Regional Tuberculosis Dispensary, Cherkasy, Ukraine.
Vitalii DidykZhytomyr Regional Tuberculosis Dispensary, Zhytomyr, Ukraine.
Olha SiomakZhytomyr Regional Tuberculosis Dispensary, Zhytomyr, Ukraine.
Dmytro ButovDepartment of Infectious Diseases, Childhood Infections and Phthisiology, Kharkiv National Medical University, Kharkiv, Ukraine.ORCID 0000-0002-8792-901X

Funding

CRDF Global DAA9-19-66199Ministry of Health of Ukraine 0123U100178National Institute of Allergy and Infectious DiseasesUS Civilian Research & Development Foundation
6 · The paper itself

Abstract

Bedaquiline, pretomanid, and linezolid, with or without moxifloxacin, have revolutionized treatment for drug-resistant tuberculosis. In Ukraine, we observed an 86% success rate (394 of 460) under programmatic conditions when drugs were accessible, exceeding prior estimates (58%) and aligning with trial findings (80%-90%). However, access and implementation remain a concern in conflict-affected settings.

Indexed as

Antitubercular AgentsDiarylquinolinesLinezolidMoxifloxacinNitroimidazolesTuberculosis, Multidrug-ResistantAdultDrug Therapy, CombinationFemaleHumansMaleMiddle AgedTreatment OutcomeUkraineAntitubercular AgentsbedaquilineDiarylquinolinesLinezolidMoxifloxacinNitroimidazolespretomanidbedaquilinelinezolidmoxifloxacinpretomanidtuberculosis

Identifiers

PMID40280886
PMCPMC12596402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.