ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2025
Depressive Symptoms Correlate With Tau Accumulation Rates in Amyloid Positive Adults.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- In the absence of Alzheimer's Disease pathology, PET-measured hippocampal tau is reduced in association with greater depressive symptoms: Could tau PET be sensitive to physiological tau involved in neurogenesis?Journal of affective disorders reports · 2026Article
- Associations of stable psychological traits with multi-omic subtypes of Alzheimer's dementia.Translational psychiatry · 2026Article
- Trajectories of late-life depression: insights from molecular imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- PET-measured tau deposition in emotion-related brain regions is differentially associated with depressive symptoms in individuals with versus without Alzheimer's disease pathology.Behavioural brain research · 2026Article
- Association between neurodegenerative plasma biomarkers and geriatric depression in older adults with and without clinical dementia in Kinshasa, Democratic Republic of the Congo.Frontiers in psychiatry · 2026Article
- Tau protein: Physiological functions and multifaceted roles in neurodegenerative and psychiatric disorders.Genomic psychiatry : advancing science from genes to society · 2025Article
- Defining the contributions of tau pathology in the amygdala to increasing depressive symptoms in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants.Frontiers in aging neuroscience · 2025Article
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8 authors.
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Abstract
objectiveDepression in Alzheimer's disease (AD) is linked to faster cognitive decline and increased tau pathology. This study examines the relationship between depressive symptoms and tau accumulation rates in older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
methodsThree-hundred and three ADNI participants with normal cognition, mild cognitive impairment, or dementia underwent serial [18F]-flortaucipir tau positron-emission tomography (PET) between 2015 and 2022. We assessed whether the Geriatric Depression Scale (GDS) score between baseline and final PET scans correlated with rates of tau accumulation in a temporal lobe meta-region of interest.
resultsGDS score was positively correlated with annualized tau accumulation rates in models adjusted for baseline tau burden, amyloid status on PET, and APOE genotype. This correlation was observed in amyloid-positive, but not amyloid-negative, participants.
conclusionDepressive symptoms in amyloid-positive adults correlate with accelerated tau accumulation, suggesting that depression may have particular relevance as an indicator of AD pathology progression, and represents a target for future research into modifiable risk factors in AD.
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