Evidence map›Paper›PMID 40280799›Full record

ReviewSeminars in fetal & neonatal medicine2025

Donor human milk pasteurization methods and the effect on milk components as they relate to Necrotizing enterocolitis.

Laiken Price, Kelly A Orgel, Misty Good

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laiken PriceDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: Laiken.Price@unchealth.unc.edu.
Kelly A OrgelDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: Kelly.Orgel@unchealth.unc.edu.
Misty GoodDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: mistygood@unc.edu.

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Point of Care maternal milk concentration device to optimize neonatal growth with targeted nutrition supportR44HD110306 · NICHD · MOTHER'S MILK IS BEST, INC. · PI Elizabeth Randall Nelson · 2023 to 2026
$4.2M
Non-invasive analysis of methylated cell free DNA in necrotizing enterocolitisR01DK124614 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, PETERS, DAVID GERARD · 2021 to 2024
$2.5M
Neonatal gut-on-a-chip platform for high content drug testing and precision medicineR01HD105301 · NICHD · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, MAGNESS, SCOTT T · 2021 to 2024
$2.4M
Reprogramming intestinal immunity in preterm neonates to prevent and cure necrotizing enterocolitisDP1DK140012 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MISTY L GOOD · 2024 to 2026
$2.2M
Modulation of the Intestinal Immune Response in Necrotizing EnterocolitisR01DK118568 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2018 to 2022
$1.8M
NICHD NIH HHS K12 HD000850NICHD NIH HHS R01 HD105301NICHD NIH HHS R44 HD110306NIDDK NIH HHS DP1 DK140012NIDDK NIH HHS R01 DK118568NIDDK NIH HHS R01 DK124614
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is an intestinal disease that predominantly occurs in preterm infants. While there are no definitive treatment options for NEC, the administration of human milk is protective against the development of NEC in preterm infants. However, human milk composition is highly dynamic, containing numerous bioactive components that can be affected by both maternal and perinatal factors. Furthermore, when maternal milk is unavailable, donor human milk, which goes through a rigorous preparation process including pooling and pasteurization, is used. The different pasteurization methods can have implications for the bioactive components of human milk. In this review, we explore the current literature surrounding the benefits of human milk in the prevention of NEC. We further review the bioactive components and the microbiome of human milk and the many factors that affect the diversity of milk content between human milk samples. Finally, we review the different methods of pasteurization and their effects on the components of human milk.

Indexed as

Enterocolitis, NecrotizingMilk, HumanPasteurizationFemaleHumansInfant, NewbornInfant, PrematureMilk BanksDonor human milkNecrotizing enterocolitisPasteurizationPrematurity

Identifiers

PMID40280799
PMCPMC12162222

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.