Evidence map›Paper›PMID 40280713›Full record

ArticleLife science alliance2025

Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling.

Prithviraj Rajebhosale, Li Jiang, Haylee J Ressa, Kory R Johnson, Niraj S Desai, Alice Jone, Lorna W Role, David A Talmage

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prithviraj RajebhosaleGenetics of Neuronal Signaling Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID 0000-0001-9893-3025
Li JiangGenetics of Neuronal Signaling Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID 0000-0001-9010-2534
Haylee J RessaUndergraduate Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA.ORCID 0009-0000-8720-8274
Kory R JohnsonBioinformatics Core, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Niraj S DesaiCircuits, Synapses and Molecular Signaling Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID 0000-0002-9969-5206
Alice JoneProgram in Neuroscience, State University of New York at Stony Brook, Stony Brook, NY, USA.
Lorna W RoleCircuits, Synapses and Molecular Signaling Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
David A TalmageGenetics of Neuronal Signaling Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA david.talmage@nih.gov.ORCID 0000-0003-4627-3007

Funding

Molecular signaling during development and maturation of the nervous systemZIANS009424 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI TALMAGE, DAVID · 2021 to 2025
$10.8M
Acetylcholine in learning and memoryZIANS009416 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ROLE, LORNA · 2021 to 2025
$9.1M
Intramural NIH HHS ZIA NS009416Intramural NIH HHS ZIA NS009424
6 · The paper itself

Abstract

Neuronal heterogeneity is a defining feature of the developing mammalian brain, but the mechanisms regulating the diversification of closely related cell types remain elusive. Here, we investigated granule cell (GC) subtype composition in the dentate gyrus (DG) and the influence of a psychosis-associated V

Indexed as

Dentate GyrusNeuregulin-1NeuronsAnimalsCell NucleusMaleMiceMice, Inbred C57BLMutationSignal TransductionNeuregulin-1Nrg1 protein, mouse

Identifiers

PMID40280713
PMCPMC12032840

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.