ArticleJournal of the American Academy of Child and Adolescent Psychiatry2026
Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- Genetic, psychological, and environmental factors are uniquely associated with onset of alcohol use in the adolescent brain cognitive development (ABCD) study.Translational psychiatry · 2025Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- The power of parenting: mitigating conduct problems among adolescents carrying genetic risk.Frontiers in child and adolescent psychiatry · 2025Article
- Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
objectiveUnderstanding how genetic risk unfolds across development will be important for using genetics to inform prevention and early intervention. The current study leverages information from 5 large datasets to characterize behavioral manifestations of a genetic liability toward externalizing from ages 6 months to 26 years.
methodWe used polygenic scores (PGS) derived from a multivariate genome-wide association study (GWAS) of externalizing that identified hundreds of significantly associated genetic variants (EXT
resultsThe EXT
conclusionA genetic liability toward externalizing is associated a wide array of behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated with a genetic liability toward externalizing could inform prevention and intervention. PLAIN LANGUAGE SUMMARY: This study leverages information from 5 large datasets to characterize behavioral manifestations of a genetic liability toward externalizing symptoms from ages 6 months to 26 years. A genetic liability toward externalizing symptoms was associated with a wide array of externalizing behaviors and psychiatric/substance use outcomes beginning as early as childhood and through emerging adulthood. The early emergence and breadth of behaviors associated with a genetic liability toward externalizing could inform prevention and intervention. STUDY REGISTRATION INFORMATION: Mapping Genetic Risk for Externalizing Behavior in Childhood, Adolescence, and Early Adulthood; https://osf.io/7g4ak/.
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