Evidence map›Paper›PMID 40280137›Full record

ArticleStem cell reports2025

What does "appropriate scientific justification" mean for the review of human pluripotent stem cell, embryo, and related research?

Erica C Jonlin, Misao Fujita, Rosario Isasi, Kazuto Kato, Megan Munsie, Kaori Muto, Kathy Niakan, Krishanu Saha, Jeremy Sugarman, Leigh Turner and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Erica C JonlinInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address: ejonlin@uw.edu.
Misao FujitaUehiro Research Division for iPS Cell Ethics, Center for iPS Cell Research and Application (CiRA), Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
Rosario IsasiDepartment of Human Genetics and Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Kazuto KatoDepartment of Biomedical Ethics and Public Policy, Graduate School of Medicine, Osaka University, Osaka, Japan.
Megan MunsieDepartment of Medicine, University of Melbourne and Murdoch Children's Research Institute, Melbourne, Australia.
Kaori MutoDepartment of Public Policy, The Institute of Medical Science, The University of Tokyo, Laboratory of Biomedical Ethics and Co-design (BECoD), RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
Kathy NiakanCentre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Krishanu SahaDepartments of Biomedical Engineering and Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Jeremy SugarmanBerman Institute of Bioethics, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Leigh TurnerDepartment of Health, Society, and Behavior, University of California, Irvine, Irvine, CA, USA.
Insoo HyunCenter for Life Sciences, Museum of Science, Boston, MA, USA; Center for Bioethics, Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This article complements the 2021 International Society for Stem Cell Research (ISSCR) Guidelines for Stem Cell Research and Clinical Translation by explaining what "adequate and appropriate scientific justification" means for human pluripotent stem cell, embryo, and related research, thus providing practical advice for review and oversight bodies, regulators, and investigators who conduct research in these areas.

Indexed as

Embryo ResearchPluripotent Stem CellsStem Cell ResearchHumans

Identifiers

PMID40280137
PMCPMC12143132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.