Evidence map›Paper›PMID 40280108›Full record

ArticleMolecular medicine reports2025

CDK5 targets p21

Min-Che Tung, Muhammet Oner, Shiuan-Woei Soong, Pang-Ting Cheng, Yu-Hsuan Li, Mei-Chih Chen, Chen-Kai Chou, Hong-Yo Kang, Frank Cheau-Feng Lin, Stella Chin-Shaw Tsai and 1 more

Abstract read
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In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min-Che TungDepartment of Surgery, Tungs' Taichung MetroHarbor Hospital, Taichung 43503, Taiwan, R.O.C.
Muhammet OnerDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan, R.O.C.
Shiuan-Woei SoongDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan, R.O.C.
Pang-Ting ChengDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan, R.O.C.
Yu-Hsuan LiDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan, R.O.C.
Mei-Chih ChenTranslational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, Taichung 40447, Taiwan, R.O.C.
Chen-Kai ChouDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 833, Taiwan, R.O.C.
Hong-Yo KangGraduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan 83301, Taiwan, R.O.C.
Frank Cheau-Feng LinSchool of Medicine, Chung Shan Medical University, Taichung 402367, Taiwan, R.O.C.
Stella Chin-Shaw TsaiDepartment of Otolaryngology, Tungs' Taichung MetroHarbor Hospital, Taichung 43503, Taiwan, R.O.C.
Ho LinDepartment of Life Sciences, National Chung Hsing University, Taichung 40227, Taiwan, R.O.C.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclin‑dependent kinase 5 (CDK5), known for its role in neuronal function, has emerged as a key player in cancer biology, particularly in thyroid cancer. The present study explored the interaction between CDK5 and the cyclin‑dependent kinase inhibitor p21

Indexed as

Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase Inhibitor p21Thyroid NeoplasmsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisCDK5 protein, humanCDKN1A protein, humanCyclin-Dependent Kinase 5Cyclin-Dependent Kinase Inhibitor p21cell proliferationcyclin‑dependent kinase 5cyclin‑dependent kinase inhibitor 1malignancypapillary thyroid cancer

Identifiers

PMID40280108
PMCPMC12059462

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.