Evidence map›Paper›PMID 40279569›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Biomedical Applications of Gadolinium-Containing Biomaterials: Not Only MRI Contrast Agent.

Xingtong Pan, Menglong Hu, Likun Wu, Erfan Wei, Qiyue Zhu, Letian Lv, Xiuyun Xv, Xinyi Dong, Hao Liu, Yunsong Liu

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Lanthanide-Doped REVOSensors (Basel, Switzerland) · 2026
    Review
  4. Review
  5. Review
  6. Biomedical Applications of Gadolinium-Containing Biomaterials: Not Only MRI Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xingtong PanDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Menglong HuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Likun WuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Erfan WeiDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Qiyue ZhuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Letian LvNational Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.
Xiuyun XvDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Xinyi DongDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Hao LiuNational Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing, 100081, China.ORCID https://orcid.org/0000-0003-0977-5884
Yunsong LiuDepartment of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.ORCID https://orcid.org/0000-0001-8364-1898

Funding

National Key R&D Program of China 2024YFF0728700National Natural Science Foundation of China 82170929National Natural Science Foundation of China 82370924Natural Science Foundation-Haidian Original Innovation Joint Fund Project L222090Natural Science Foundation-Haidian Original Innovation Joint Fund Project L222145Young Beijing Scholars Program 2024-089
6 · The paper itself

Abstract

The potential applications of rare earth elements (REEs) in biomedical fields have been intensively investigated. Numerous studies have shown that doping biomaterials with REEs can enhance their properties. Gadolinium (Gd) is a biocompatible REE that holds promise in biomedical applications. This review examines the use of Gd-doped biomaterials in osteogenic, antimicrobial, anticancer applications, and in bioimaging and bioprobes, as reported in the literature until December 2024. The included studies demonstrate that Gd-containing biomaterials promote osteogenesis, enhance antimicrobial properties, and perform well in anticancer applications and bioimaging. Taken together, they point to the considerable potential of Gd-doped biomaterials and thus to avenues for future research.

Indexed as

Biocompatible MaterialsContrast MediaGadoliniumMagnetic Resonance ImagingAnimalsHumansOsteogenesisBiocompatible MaterialsContrast MediaGadoliniumanticancerantimicrobialbio‐imagingGadoliniumosteogenesis

Identifiers

PMID40279569
PMCPMC12120756

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.