ArticleEnvironmental science & technology2025
Associations of Serum Per- and Polyfluoroalkyl Substances with Genotoxic Biomarkers: New Insights from Cross-Sectional and In Vivo Evidence.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Per- and Polyfluoroalkyl Substances Exposure and Ischemic Heart Disease: Emerging Evidence from the Literature.Antioxidants (Basel, Switzerland) · 2026Review
- Urine-to-Blood Partitioning of Per- and Polyfluoroalkyl Substances in Human Biomonitoring: Implications for Environmental Exposure Analysis and Bioaccumulation Assessment.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) on genomic stability remain unclear. Here, a cross-sectional study was conducted to establish the associations of PFAS with genotoxic biomarkers. We recruited a cohort of 453 residents in 2021 in Zhejiang, China. Thirty PFAS in serum were quantified, alongside seven indicators of genomic stability [five rDNA copy numbers (rDNA-CN), mitochondrial DNA copy numbers (mtDNA-CN), and relative telomere length (RTL)] in whole blood. Results showed that PFUnDA, perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), 6:2 Cl-PFESA, and PFO5DoDA were positively correlated with rDNA-CN, while PFHpA, PFOA, and PFMOAA showed inverse associations. PFO4DA and PFO5DoDA were positively correlated with mtDNA-CN. PFOA, HFPO-TA, and PFMOAA were negatively associated with the RTL, while perfluorononanoic acid, PFHxS, PFOS, and 6:2 Cl-PFESA showed positive associations. Nonlinear exposure-response relationships were also observed between PFAS and genotoxic biomarkers using restricted cubic spline models. Furthermore, PFAS mixtures were positively associated with mtDNA-CN, with PFO5DoDA showing the highest contribution by the quantile-based g-computation model. In vivo studies further confirmed that PFO5DoDA increased mtDNA-CN in male mice in a dose-dependent manner. This study provides novel evidence that PFAS disrupt genomic stability, with effects varying by functional groups and fluoroalkyl(ether) chain lengths.
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Registered trials
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