ArticleJournal of chemical information and modeling2025
Impact of Native Environment in Multiheme-Cytochrome Chains of the MtrCAB Complex.
Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Decoding microbial diversity, biogeochemical functions, and interaction potentials in red sea hydrothermal vents.Environmental microbiome · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
MtrCAB protein complex plays a crucial role in exporting electrons through the outer membrane (OM) to external acceptors. This complex consists of three proteins and contains 20 hemes. Optimal protein-protein interactions and, consequently, heme-heme interactions facilitate efficient electron transfer through the conduit of hemes. The cytochrome MtrA remains mostly inside porin MtrB, and the MtrB barrel contains two calcium ions on its surface. In this study, we investigate the effect of porin-bound calcium ions on the heme-heme distances in the twenty-heme network. We performed all-atom molecular dynamics simulations of the OM-protein complex, MtrCAB, in the presence and absence of the MtrB-bound calcium ions. We observe that the calcium ions bound to MtrB affect the interfacial heme-heme distance when all of the hemes are oxidized and impact one of the heme-heme distances in MtrC when all of the hemes are reduced. In both cases, the absence of calcium ions increases the heme-heme distance, highlighting the crucial role of calcium ions in maintaining the heme network, which is essential for long-range charge transport.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.