ArticleScience advances2025
Growth rate controls the sensitivity of gene regulatory circuits.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Growth control as a central regulator for tuning the cellular context.Journal of biological engineering · 2026Article
- Coupled Perturbations of Gene Circuit Dynamics by Resource Competition and Growth Dilution.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Article
- Fundamental errors in RNA velocity arising from the omission of cell growth.bioRxiv : the preprint server for biology · 2025Article
- Resource-use plasticity governs the causal relationship between traits and community structure in model microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Effective bet-hedging through growth rate dependent stability.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Navigating Environmental Transitions: the Role of Phenotypic Variation in Bacterial Responses.mBio · 2022Review
- Bacterial degrons in synthetic circuits.Open biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbes adapt to their environments using gene regulatory switches that sense environmental signals and induce target genes in response. Mathematical modeling predicts that, because growth rate sets the intracellular dilution rate, the sensitivity of regulatory switches to chemical cues systematically decreases with growth rate. We experimentally validate that the concentration of inducer required to activate
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.