Evidence map›Paper›PMID 40279276›Full record

ArticleRheumatology (Oxford, England)2025

Incidence and prevalence of Behçet's disease in Oslo, Norway: a two-decade population-based analysis.

Jing Lisa Li Lorentsen, Cathrine Brunborg, Anders T Aasebø, Jørgen Valeur, Espen A Haavardsholm, Øyvind Molberg, Øyvind Palm, Karoline Lerang

Abstract read
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Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jing Lisa Li LorentsenDepartment of Rheumatology, Østfold Hospital, Moss, Norway.ORCID 0000-0002-2350-483X
Cathrine BrunborgOslo Center for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-9050-2968
Anders T AasebøDepartment of Internal Medicine, Akershus University Hospital, Lørenskog, Norway.
Jørgen ValeurUnger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.ORCID 0000-0001-7193-7069
Espen A HaavardsholmInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-1427-4745
Øyvind MolbergInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-4493-8853
Øyvind PalmDepartment of Rheumatology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-5395-0665
Karoline LerangDepartment of Rheumatology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-2326-5875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate the incidence and prevalence of Behçet's disease (BD) in Oslo, Norway from 1999 to 2021.

methodsFirst, we identified BD cases from the Oslo hospital administrative databases and Norwegian connective tissue and vasculitis registry (NOSVAR) using the code for BD (M35.2) of the 10th revised edition of the International Classification of Diseases. Next, all identified cases were manually chart-reviewed and classified by the International Study Group (ISG) criteria and International Criteria for Behçet's Disease (ICBD). Cases meeting at least one of the two criteria were included.

resultsIn total 58 patients were included, 43 of them incidental; 52% were female and 57% with non-Norwegian ancestry. The mean age at symptom onset was 24 years and at diagnosis 33 years. The median diagnostic delay was 5 (interquartile range 2-12) years. Incidence was 0.29 (95% CI: 0.18, 0.41) per 100 000 person-years, higher in non-Norwegians (0.44 vs 0.22). Among Norwegians, the incidence was higher in females (0.27 vs 0.08). The prevalence was 2.36 per 100 000 inhabitants in 1999 and 7.14 in 2021, higher for non-Norwegians (12.68 vs 4.32 in 2021). Incidence and prevalence appeared to increase, but reclassification by ISG criteria adjusted the trend downward. This trend was significantly reduced when accounting for the proportion of non-Norwegians.

conclusionBD is a rare disease in Oslo, Norway, with female predominance in Norwegian descendants, but higher prevalence overall in non-Norwegians. The observed increases in incidence and prevalence are likely due to changes in population genetics and introduction of the more sensitive ICBD criteria. Diagnostic delays are common, a significant concern, in Behçet's disease.

Indexed as

Behcet SyndromeAdolescentAdultFemaleHumansIncidenceMaleMiddle AgedNorwayPrevalenceRegistriesYoung AdultBehçet’s diseasediagnostic delayepidemiologyincidenceNorwayOslopopulation geneticsprevalence

Identifiers

PMID40279276
PMCPMC12316381

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