Evidence map›Paper›PMID 40279260›Full record

ArticleeLife2025

Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications.

Ida Marie Boisen, Nadia Krarup Knudsen, John E Nielsen, Ireen Kooij, Mathilde Louise Bagger, Jovanna Kaludjerovic, Peter O'Shaughnessy, Peter W Andrews, Noriko Ide, Birgitte G Toft and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. TGFβ signaling regulates the response of the skeleton to phosphate.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Soft tissue calcifications in chronic kidney disease-beyond the vasculature.Pflugers Archiv : European journal of physiology · 2025
    Review
  5. Observational
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ida Marie BoisenDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.ORCID https://orcid.org/0000-0003-2401-2877
Nadia Krarup KnudsenDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.ORCID https://orcid.org/0009-0005-1591-343X
John E NielsenDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ireen KooijDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.
Mathilde Louise BaggerDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.
Jovanna KaludjerovicDivision of Bone and Mineral Research, Harvard School of Dental Medicine/Harvard Medical School, Harvard University, Boston, United States.
Peter O'ShaughnessySchool of Biodiversity, One Health & Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0001-5651-7883
Peter W AndrewsCentre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, United Kingdom.
Noriko IdeDivision of Bone and Mineral Research, Harvard School of Dental Medicine/Harvard Medical School, Harvard University, Boston, United States.
Birgitte G ToftDepartment of Pathology, Rigshospitalet, Copenhagen, Denmark.
Anders JuulDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Arnela MehmedbasicDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.ORCID https://orcid.org/0009-0006-3680-247X
Anne JørgensenDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.
Lee B SmithMRC Centre for Reproductive Health, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, United Kingdom.
Richard NormanDepartment of Urology, Dalhousie University, Halifax, Canada.
Ewa Rajpert-De MeytsDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Beate LanskeDivision of Bone and Mineral Research, Harvard School of Dental Medicine/Harvard Medical School, Harvard University, Boston, United States.
Martin Blomberg JensenDivision of Translational Endocrinology, Department of Endocrinology and Internal Medicine, University Hospital Copenhagen, Herlev-Gentofte, Herlev, Denmark.ORCID https://orcid.org/0000-0003-3800-4253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Testicular microcalcifications consist of hydroxyapatite and have been associated with an increased risk of testicular germ cell tumors (TGCTs) but are also found in benign cases such as loss-of-function variants in the phosphate transporter

Indexed as

CalcinosisFibroblast Growth FactorsHomeostasisMineralsNeoplasms, Germ Cell and EmbryonalTesticular DiseasesTesticular NeoplasmsTestisAnimalsFibroblast Growth Factor-23HumansMaleMiceMice, KnockoutFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23Fibroblast Growth FactorsMineralscancer biologycell biologyFgf23humanhydroxyapatitemicrolithiasismineral homeostasismouseSertoli cell dysfunctiontestis

Identifiers

PMID40279260
PMCPMC12029210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.