Evidence map›Paper›PMID 40279247›Full record

ArticleCell reports2025

Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.

Cameron Miller, Alyssa Ealy, Amanda Gregory, Chelva Janarthanam, William Albers, Gabriel Richardson, Huajun Jin, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Targeting mNature communications · 2026
    Article
  4. mNature reviews. Neuroscience · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cameron MillerIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, GA 30602, USA.
Alyssa EalyIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Physiology and Pharmacology, The University of Georgia, Athens, GA 30602, USA.
Amanda GregoryIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA.
Chelva JanarthanamIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Physiology and Pharmacology, The University of Georgia, Athens, GA 30602, USA.
William AlbersIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Biology, The University of Georgia, Athens, GA 30602, USA.
Gabriel RichardsonIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA.
Huajun JinIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Physiology and Pharmacology, The University of Georgia, Athens, GA 30602, USA.
Gary ZenitskyIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA.
Vellareddy AnantharamIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Physiology and Pharmacology, The University of Georgia, Athens, GA 30602, USA.
Arthi KanthasamyIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, GA 30602, USA.
Anumantha G KanthasamyIsakson Center for Neurological Disease Research, The University of Georgia, Athens, GA 30602, USA; Department of Biology, The University of Georgia, Athens, GA 30602, USA; Department of Biochemistry and Molecular Biology, The University of Georgia, Athens, GA 30602, USA; Department of Physiology and Pharmacology, The University of Georgia, Athens, GA 30602, USA. Electronic address: anumantha.kanthasamy@uga.edu.

Funding

Compensatory Mitochondrial Protective Mechanisms Against Oxidative Stress in PDR01NS121692 · NINDS · UNIVERSITY OF GEORGIA · PI ARTHI KANTHASAMY, Anumantha Gounder Kanthasamy · 2022 to 2026
$2.2M
The Role of KCa3.1 in Microglial function and in Parkinsons disease pathogenesisR01NS124226 · NINDS · UNIVERSITY OF GEORGIA · PI ARTHI KANTHASAMY, HEIKE WULFF · 2021 to 2026
$1.9M
Novel Mechanisms of Pesticide-Induced NeurotoxicityR01ES027245 · NIEHS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2017 to 2021
$1.7M
Novel Epitranscriptomic Mechanisms in Metal NeurotoxicityR01ES036241 · NIEHS · UNIVERSITY OF GEORGIA · PI ARTHI KANTHASAMY, Anumantha Gounder Kanthasamy · 2025 to 2026
$890k
NIEHS NIH HHS R01 ES027245NIEHS NIH HHS R01 ES036241NINDS NIH HHS R01 NS121692NINDS NIH HHS R01 NS124226
6 · The paper itself

Abstract

Recent reports suggest dysregulation of the N6-methyladenosine (m6A) RNA modification may contribute to the pathology of neurodegenerative diseases. Herein, we show the m6A methyltransferase complex including METTL3-the catalytic component of the nuclear-localized complex-is robustly upregulated in human microglia and astrocytes exposed to αSyn

Indexed as

alpha-SynucleinMethyltransferasesMicrogliaMixed DementiasAnimalsBrainEpigenomicsGene Expression ProfilingHumansImmunohistochemistryManganeseMiceNeuroinflammatory DiseasesPostmortem Imagingalpha-SynucleinManganeseMethyltransferasesMETTL3 protein, humanAlzheimer’s diseaseCP: Molecular biologyCP: Neurosciencem6AmanganeseMETTL3microglianeuroinflammationneurotoxicityParkinson’s disease

Identifiers

PMID40279247
PMCPMC12219090

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.