Evidence map›Paper›PMID 40279245›Full record

ArticleCell reports2025

Loss of neurofibromin induces inflammatory macrophage phenotypic switch and retinal neovascularization via GLUT1 activation.

Yusra Zaidi, Rebekah Tritz, Nida Zaidi, Faisal Nabi, Syed Adeel H Zaidi, Abdelhakim Morsy, Valerie Harris, Rilee Racine, Farlyn Z Hudson, Zsuzsanna Bordan and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Frontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yusra ZaidiVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Rebekah TritzVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Nida ZaidiInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP 202001, India.
Faisal NabiInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP 202001, India.
Syed Adeel H ZaidiVascular Biology Center, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Abdelhakim MorsyVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Ophthalmology, Al-Azhar University, Cairo, Egypt.
Valerie HarrisVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Rilee RacineVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Farlyn Z HudsonVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Zsuzsanna BordanVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Simone KennardVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Robert BatoriVascular Biology Center, Augusta University, Augusta, GA 30912, USA.
Yuqing HuoVascular Biology Center, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Gabor CsanyiVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Eric J Belin de ChantemèleVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Kecheng LeiDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Nicholas M BoulisDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
David J FultonVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Rizwan Hasan KhanInterdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP 202001, India.
Ruth B CaldwellVascular Biology Center, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Brian K StansfieldVascular Biology Center, Augusta University, Augusta, GA 30912, USA; Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA; James and Jean Culver Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. Electronic address: bstansfield@augusta.edu.

Funding

Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Myeloid glycolysis in pathological ocular angiogenesisR01EY030500 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2019 to 2023
$2.6M
Novel mechanisms of HIV-associated pulmonary vascular diseaseR01HL176323 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele, Laszlo Kovacs · 2024 to 2026
$2.3M
SMC macropinocytosis: a novel target in atherosclerotic vascular diseaseR01HL164792 · NHLBI · AUGUSTA UNIVERSITY · PI Gabor Csanyi · 2023 to 2026
$2.2M
Inflammation and retinopathy of prematurityR01EY029318 · NEI · AUGUSTA UNIVERSITY · PI STANSFIELD, BRIAN KEVIN · 2019 to 2023
$2.2M
Mechanism of cardiovascular disease in premenopausal womenR01HL155265 · NHLBI · AUGUSTA UNIVERSITY · PI BELIN DE CHANTEMELE, ERIC J · 2021 to 2024
$2.1M
Adenosine receptor 2A in subretinal fibrosisR01EY033737 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Ruth B Caldwell, YUQING HUO · 2022 to 2026
$2.1M
Mechanisms of HIV-associated HypertensionR01HL175471 · NHLBI · AUGUSTA UNIVERSITY · PI Eric J Belin de Chantemele · 2024 to 2026
$2.0M
"Myeloid PFKFB3 in subretinal fibrosis"R01EY033369 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2022 to 2025
$1.6M
Myeloid ACAT1 in ischemic retinopathyR01EY035683 · NEI · AUGUSTA UNIVERSITY · PI Ruth B Caldwell, Modesto Antonio Rojas · 2024 to 2026
$1.2M
NEI NIH HHS P30 EY031631NEI NIH HHS R01 EY029318NEI NIH HHS R01 EY030500NEI NIH HHS R01 EY033369NEI NIH HHS R01 EY033737NEI NIH HHS R01 EY035683NHLBI NIH HHS R01 HL155265NHLBI NIH HHS R01 HL164792NHLBI NIH HHS R01 HL175471NHLBI NIH HHS R01 HL176323
6 · The paper itself

Abstract

Persons with neurofibromatosis type 1 (NF1) exhibit enhanced glucose metabolism, which is replicated in Nf1-mutant mice. Inflammatory macrophages invest NF1-associated tumors, and targeting macrophages appears efficacious in NF1 models. Inflammatory macrophages rely on glycolysis to generate ATP; thus, identifying whether neurofibromin, the protein encoded by NF1, controls glucose metabolism in macrophages is therapeutically compelling. Using neurofibromin-deficient macrophages and macrophage-specific Nf1-knockout mice, we demonstrate that neurofibromin complexes with glucose transporter-1 (GLUT1) to restrain its activity and that loss of neurofibromin permits Akt2 to facilitate GLUT1 translocation to the membrane. In turn, glucose internalization and glycolysis are upregulated and provoke reparative (M

Indexed as

Glucose Transporter Type 1InflammationMacrophagesNeurofibromin 1Retinal NeovascularizationAnimalsGlucoseGlycolysisHumansMiceMice, KnockoutNeurofibromatosis 1PhenotypeProto-Oncogene Proteins c-aktGlucoseGlucose Transporter Type 1Neurofibromin 1Proto-Oncogene Proteins c-aktSlc2a1 protein, mouseAkt2CP: ImmunologyCP: Metabolismglucose transporter-1glucose uptakeglycolysisinflammationmacrophagesneurofibrominpathological neovascularization

Identifiers

PMID40279245
PMCPMC12184535

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.