Evidence map›Paper›PMID 40279189›Full record

Trial reportClinical and translational science2025

Bioequivalence and Food Effect Assessment of Two Fixed-Dose Combination Formulations of Telmisartan-Hydrochlorothiazide Tablets in Chinese Healthy Subjects.

Minwan Hu, Man Yang, Shuyu Zhang, Jiangfan Li, Hongxian Pang, Yingzi Pei, Chao Guo, Xuhong Wang

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Minwan HuDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, People's Republic of China.
Man YangDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, People's Republic of China.
Shuyu ZhangAnesthesiology Class 211, First Clinical Medical College of Nanchang University, Nanchang, People's Republic of China.
Jiangfan LiDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, People's Republic of China.
Hongxian PangDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, People's Republic of China.
Yingzi PeiDepartment of Clinical Pharmacology, Beijing Fuyuan Pharmaceuticals co., Ltd., Beijing, People's Republic of China.
Chao GuoDepartment of Clinical Pharmacology, Beijing Fuyuan Pharmaceuticals co., Ltd., Beijing, People's Republic of China.
Xuhong WangDepartment of Clinical Pharmacology, Affiliated Beijing Luhe Hospital of Capital Medical University, Beijing, People's Republic of China.ORCID 0009-0004-4855-208X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the bioequivalence and food effect of two fixed-dose combination (FDC) formulations of telmisartan-hydrochlorothiazide tablets (telmisartan 40 mg, hydrochlorothiazide 12.5 mg) in healthy Chinese subjects. Seventy-two subjects were enrolled and divided into fasted and fed cohorts in a single-center, randomized, open-label, single-dose, three-period, three-sequence, and crossover study. The pharmacokinetic characteristics of telmisartan and hydrochlorothiazide, including C

Indexed as

BenzimidazolesFood-Drug InteractionsHydrochlorothiazideTelmisartanAdministration, OralAdultArea Under CurveBenzoatesChinaCross-Over StudiesDrug CombinationsEast Asian PeopleFastingFemaleHealthy VolunteersHumansBenzimidazolesBenzoatesDrug CombinationsHydrochlorothiazideTabletsTelmisartantelmisartan, hydrochlorothiazide drug combinationbioequivalencefixed‐dose combination (FDC)hydrochlorothiazidepharmacokineticstelmisartan

Identifiers

PMID40279189
PMCPMC12024483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.