Evidence map›Paper›PMID 40279046›Full record

ArticleDiscover oncology2025

The regulatory role of PTTG1 in proliferation and migration of thyroid cancer.

Jianjun Wang, Chenjun Guo, Junyu Cao, Li Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jianjun Wang *Department of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, Yunnan, China.
Chenjun Guo *Department of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, Yunnan, China.
Junyu CaoDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, Yunnan, China.
Li LiDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, Yunnan, China. ynLilidoctor@126.com.

Funding

Science and Technology Program of the Department of Science and Technology of Yunnan Province 202101AY070001-239
6 · The paper itself

Abstract

purposeTo investigate the role of PTTG1 in thyroid cancer, focusing on its impact on proliferation, migration, and the regulation of p53-related signaling pathways.

methodsWe analyzed PTTG1 expression in thyroid cancer samples by using the TCGA database and validated our findings in tissue samples and cell lines. Functional assays including knockdown experiments using shRNA, CCK-8 assays for proliferation, scratch wound healing and Transwell assays for migration, and in vivo tumorigenesis experiments in mice were conducted. Expression levels of cell cycle markers (p27, p21, CDK1, p53) were assessed by qPCR and western blot.

resultsPTTG1 expression was significantly upregulated in thyroid cancer tissues and cells, correlating with reduced overall survival in patients. Knockdown of PTTG1 in thyroid cancer cells led to decreased proliferation and migration capabilities, as demonstrated by CCK-8 and clonogenic assays, scratch wound healing, Transwell assays, and reduced tumor growth in vivo. Mechanistically, PTTG1 downregulation resulted in increased expression of p53 and its downstream effectors, suggesting a role for PTTG1 in suppressing the p53-related signaling pathway.

conclusionElevated PTTG1 expression promotes proliferation and migration of thyroid cancer cells and correlates with poor patient survival.

Indexed as

MigrationProliferationPTTG1Thyroid cancer

Identifiers

PMID40279046
PMCPMC12031701

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