ArticleMolecular neurobiology2025
Association Between T2DM, TyG Index, Multiple Sclerosis, and Rheumatoid Arthritis: Insights into Potential Mechanisms.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Association of Glycemic Status with Disability, Relapse Activity, Inflammatory Markers, and Metabolic Profile in Patients with Multiple Sclerosis.Journal of clinical medicine · 2026Article
- Association of the triglyceride-glucose index with the severity and short-term prognosis of Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- Associations Between Dietary Factors, Metabolic Factors, Sleep Disorders, Physical Activity, and the Risk of Multiple Sclerosis: A Univariable and Multivariable Mendelian Randomization Study.Food science & nutrition · 2025Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Abundant research indicates that type 2 diabetes mellitus (T2DM) and insulin resistance (IR) have a certain association with autoimmune-related diseases (ARDs). However, the conclusions remain elusive. Therefore, this study aimed to explore whether there are causal associations between T2DM and IR indicator, triglyceride-glucose (TyG) index with ARDs, and evaluate the impact of immune cells. Comprehensive Mendelian randomization (MR) analysis combined with Bayesian colocalization was employed to investigate the relationship between T2DM, TyG index, ARDs, and specific-marker immune cells by extracting summary-level data from various genome-wide association studies (GWASs). Further investigations utilizing single-cell RNA sequencing (scRNA-seq) analysis were performed to explore the potential molecular mechanisms underlying the MR analysis results. Causal associations of T2DM with multiple sclerosis (MS) and rheumatoid arthritis (RA) were detected. Additionally, the TyG index was genetically predicted to be associated with MS. Furthermore, immune cells were found to be related to T2DM and TyG index, of which CD3 on naive CD8 + T cell mediate the effect on the association between TyG index and multiple sclerosis (MS). Additionally, genetic variation of TCF7L2 and TNFSF13B were assessed to play a crucial role in the aforementioned associations supported by colocalization analysis. This study identified T2DM and IR related to increased risk of MS and RA. The analysis of relevant immune cells and shared genetic loci provides a novel direction for exploring comorbidity mechanisms.
Indexed as
Identifiers
40279037What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.