Evidence map›Paper›PMID 40278931›Full record

ArticleWorld journal of urology2025

Acidic urine as a prognostic factor after intravesical Bacillus Calmette-Guérin induction therapy for nonmuscle-invasive bladder cancer.

Hoyoung Ryu, Sangchul Lee, Sang Hun Song, Hakmin Lee, Jong Jin Oh, Sung Kyu Hong, Seok-Soo Byun, Byeongdo Song

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Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hoyoung Ryu *Department of Urology, Ewha Womans University Mokdong Hospital, Seoul, Korea.
Sangchul Lee *Department of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Sang Hun SongDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Hakmin LeeDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Jong Jin OhDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Sung Kyu HongDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Seok-Soo ByunDepartment of Urology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Byeongdo SongDepartment of Urology, Hanyang University College of Medicine, Seoul, Korea. dreamofkgr@naver.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effect of acidic urine (pH ≤ 5.5) on disease recurrence or progression in patients with nonmuscle-invasive bladder cancer (NMIBC) undergoing transurethral resection of bladder tumor (TURBT) followed by intravesical Bacillus Calmette-Guérin (BCG) induction therapy.

methodsA total of 578 patients with intermediate- and high-risk NMIBC who underwent intravesical BCG induction after initial TURBT between May 2003 and April 2021 were included. Patients were subdivided into low (pH ≤ 5.5) and high (pH > 5.5) urine pH groups.

resultsPatients with acidic urine showed higher fasting plasma glucose levels (p = 0.017), higher serum uric acid level (p = 0.011), lower estimated glomerular filtration rates (p = 0.022), and higher rates of abnormal urinary cytology (p = 0.021), but no significant differences were observed in context of adverse clinicopathological features. During a median follow-up period of 56 months, the acidic urine group had a lower recurrence-free survival rate than the high urine pH group (p = 0.009). In terms of disease progression, there was no difference according to urine pH status.

conclusionAcidic urine was associated with disease recurrence after intravesical BCG induction for NMIBC, despite no differences in adverse clinicopathological features according to urine acidity.

Indexed as

Adjuvants, ImmunologicBCG VaccineUrinary Bladder NeoplasmsUrineAdministration, IntravesicalAgedAged, 80 and overDisease ProgressionFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalPrognosisAdjuvants, ImmunologicBCG VaccineIntravesical BCG inductionIntravesical recurrenceNonmuscle-invasive bladder cancerUrine pHUrothelial carcinoma

Identifiers

PMID40278931

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