Evidence map›Paper›PMID 40278923›Full record

ArticleClinical oral investigations2025

Characterization of hypomineralization second primary molar and molar incisor hypomineralization in patients with orofacial clefts.

Aline Leite de Farias, Diego Fernando Rojas-Gualdrón, Manuel Restrepo, Karina Gottardello Zecchin, Diego Girotto Bussaneli, Kasandra Yupanqui, Cassio Eduardo Raposo-Amaral, Lourdes Santos-Pinto

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cleft lip and palate are associated with a higher prevalence of molar-incisor hypomineralisation: a cross-sectional study with a comparison group.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aline Leite de FariasBasic and Clinical Research Group in Dentistry, School of Dentistry, CES University, Medellín, Colombia. aleite@ces.edu.co.
Diego Fernando Rojas-GualdrónSchool of Medicine, CES University, Medellín, Colombia.
Manuel RestrepoBasic and Clinical Research Group in Dentistry, School of Dentistry, CES University, Medellín, Colombia.
Karina Gottardello ZecchinDepartment of Pediatric Dentistry, Care for patients with special needs, UZ Leuven, Leuven, Belgium.
Diego Girotto BussaneliDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.
Kasandra YupanquiDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.
Cassio Eduardo Raposo-AmaralInstitute of Plastic and Craniofacial Surgery, SOBRAPAR, Hospital, Campinas, São Paulo, Brazil.
Lourdes Santos-PintoDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

aimsTo identify and characterize hypomineralization in the second primary molar (HSPM) and molar incisor hypomineralization (MIH), as well as other developmental defects of enamel (DDE) in patients with clefts considering dentition type, tooth type, phenotype and cleft laterality. MATERIALS AND

methodsIn this cross-sectional retrospective study, 6432 deciduous and permanent teeth of 290 patients with clefts aged between 3 and 14 years in a referral hospital were assessed using intraoral photographs. The classification of demarcated hypomineralization was carried out by a calibrated examiner using the MIH index. Statistical analyses were performed using a binomial generalized linear model.

resultsDeciduous and permanent molars were the most affected by HSPM and MIH, whereas incisors and canines were most affected by hypoplasia, with the upper arch being most affected by DDE. Cleft phenotypes involving the palate were associated with HSPM (OR = 31; 95% CI: 1.0-59.3) and MIH (OR = 31.6; 95% CI: 0.6-53.2).

conclusionPatients with clefts had a high prevalence of HSPM and MIH in the upper arch and were associated with more severe cleft phenotypes. CLINICAL RELEVANCE: Pediatric dentists who are members of the multidisciplinary teams responsible for caring for patients with clefts need to have a more discerning clinical eye when diagnosing DDE in patients with clefts. Posterior teeth are more susceptible to demarcated hypomineralizations in patients with clefts, while anterior teeth are more susceptible to hypoplasias.

Indexed as

Cleft LipCleft PalateDental Enamel HypoplasiaIncisorMolarAdolescentChildChild, PreschoolCross-Sectional StudiesFemaleHumansMaleMolar HypomineralizationPhenotypePhotography, DentalRetrospective StudiesCleft lipCleft lip and palateCleft palateDental enamelDental enamel hypomineralizationDental enamel hypoplasia

Identifiers

PMID40278923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.