Evidence map›Paper›PMID 40278889›Full record

ArticleExperimental brain research2025

Darbepoetin alpha has neuroprotective effects in the hippocampus against long-term intermittent ethanol administration.

Emine Uygur, Hafize Uzun, Matem Tuncdemir, Aysim Buge Oz, Elif Polat, Ahsen Yilmaz, Elif Yaman, Hakki Oktay Seymen

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Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Emine UygurDepartment of Physiology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, 59030, Turkey. fztemine68@hotmail.com.ORCID http://orcid.org/0000-0002-0620-1175
Hafize UzunDepartment of Medical Biochemistry, Faculty of Medicine, Atlas University, Istanbul, 34408, Turkey.
Matem TuncdemirDepartment of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, 34098, Turkey.
Aysim Buge OzDepartment of Medical Pathology, Co-Founder, Chair of Scientific and Medical Advisory Board, Pathern Laboratories, Istanbul, 34140, Turkey.
Elif PolatDepartment of Histology and Embryology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, 59030, Turkey.
Ahsen YilmazDepartment of Medical Biochemistry, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, 59030, Turkey.
Elif YamanDepartment of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, 34098, Turkey.
Hakki Oktay SeymenDepartment of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University Cerrahpasa, Istanbul, 34098, Turkey.

Funding

Istanbul University-Cerrahpasa Scientific Research Projects Coordination Unit TDK-2020-34657
6 · The paper itself

Abstract

The consumption of ethanol has detrimental effects on several organs, including the brain. One of the most important targets of ethanol toxicity in the brain is the hippocampus. The aim of our study was to investigate the neuroprotective effects of darbepoetin alpha against neuronal damage caused by long-term intermittent ethanol exposure in the hippocampus. Forty male Wistar albino rats were divided into four groups: control (C), ethanol (E), darbepoetin alpha (DA), and ethanol + darbepoetin alpha (E + DA). In this study, oxidative stress and antioxidant markers, S100-β and neuron specific enolase (NSE) were investigated in both brain tissue and serum. Additionally, brain tissues were examined using histopathological methods. S100-β and NSE levels were significantly elevated in the E group compared to the C group in both the brain tissue and serum. Furthermore, catalase (CAT) and glutathione reductase (GR) levels, glutathione peroxidase (GPx) enzyme activities were significantly lower in both brain tissue and serum, while superoxide dismutase (SOD) enzyme activity in brain tissue was significantly reduced, and malondialdehyde (MDA) levels in brain tissue were markedly elevated in the E group. In the E + DA group, S100-β levels in both brain tissue and serum, NSE levels in serum, and MDA levels in brain tissue were significantly lower. Additionally, GPx activity in brain tissue and CAT levels in serum were significantly higher in the E + DA group compared to the E group. Histopathologically, the E group showed moderate neurodegeneration in the dentate gyrus, while the E + DA group exhibited mild neurodegeneration. In conclusion, DA reversed the degenerative effects of long-term intermittent ethanol exposure on the hippocampus by improving oxidative stress parameters and reducing neuronal injury.

Indexed as

Central Nervous System DepressantsDarbepoetin alfaEthanolHippocampusNeuroprotective AgentsAnimalsCatalaseMaleMalondialdehydeOxidative StressPhosphopyruvate HydrataseRatsRats, WistarS100 Calcium Binding Protein beta SubunitSuperoxide DismutaseCatalaseCentral Nervous System DepressantsDarbepoetin alfaEthanolMalondialdehydeNeuroprotective AgentsPhosphopyruvate HydrataseS100 Calcium Binding Protein beta SubunitSuperoxide DismutaseDarbepoetin alphaEthanol exposureHippocampusNeurodegenerationNeuroprotection

Identifiers

PMID40278889

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.