Evidence map›Paper›PMID 40278857›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2025

Head-to-head comparison of fibroblast activation protein inhibitors (FAPI) radiopharmaceuticals and [

Anita Florit, Elizabeth J de Koster, Serena Sassano, Lejla Alic, Giusi Pisano, Floris H P van Velden, Salvatore Annunziata, Irina Primac, Maria Rosaria Ruggiero, Cristina Müller and 7 more

Abstract readSystematic ReviewMeta-AnalysisComparative Study
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Clinical Evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. [Current oncology (Toronto, Ont.) · 2026
    Article
  3. Comparison of [Abdominal radiology (New York) · 2026
    Article
  4. Comparative Performance ofWorld journal of nuclear medicine · 2026
    Article
  5. Review
  6. Dual-receptor PET imaging of ovarian cancer using aAmerican journal of nuclear medicine and molecular imaging · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Anita FloritNuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy.ORCID 0000-0003-0469-6335
Elizabeth J de KosterDepartment of Surgery, Haaglanden Medical Centre, The Hague, The Netherlands.ORCID 0000-0001-8111-1172
Serena SassanoSection of Nuclear Medicine, Department of Radiological Sciences and Haematology, Università Cattolica del Sacro Cuore, Rome, Italy.
Lejla AlicMagnetic Detection & Imaging Group, Technical Medical Centre, University of Twente, Enschede, The Netherlands.ORCID 0000-0001-6487-6958
Giusi PisanoSection of Nuclear Medicine, Department of Radiological Sciences and Haematology, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0001-9627-5065
Floris H P van VeldenSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-2859-2119
Salvatore AnnunziataNuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy.ORCID 0000-0003-3241-1501
Irina PrimacRadiobiology Unit, Nuclear Medical Applications Institute, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.ORCID 0000-0001-7989-5027
Maria Rosaria RuggieroPET/CT Centre, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.ORCID 0000-0003-2374-6692
Cristina MüllerCentre for Radiopharmaceutical Sciences, PSI Center for Life Sciences, Villigen-PSI, Switzerland.ORCID 0000-0001-9357-9688
Evis SalaSection of Radiology, University Department of Radiological Sciences and Haematology, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID 0000-0002-5518-9360
Wolfgang P FendlerDepartment of Nuclear Medicine, DKTK and NCT University Hospital Essen, Essen, Germany.ORCID 0000-0002-5106-3584
Giovanni ScambiaGynaecologic Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.ORCID 0000-0002-9503-9041
Lioe-Fee de Geus-OeiBiomedical Photonic Imaging Group, University of Twente, Enschede, The Netherlands.ORCID 0000-0003-1817-2743
Anna FagottiGynaecologic Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.ORCID 0000-0001-5579-335X
Vittoria RufiniNuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy. vittoria.rufini@unicatt.it.ORCID 0000-0002-1045-0633
Angela CollarinoNuclear Medicine Unit, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy.ORCID 0000-0001-6162-9767

Funding

Innovative Health Initiative 101172788
6 · The paper itself

Abstract

purposeThis study aims to systematically review and perform a meta-analysis to compare the diagnostic performance of fibroblast activation protein inhibitors (FAPI) radiopharmaceuticals and 2-deoxy-2-[

methodsA comprehensive search of PubMed/MEDLINE and EMBASE was conducted and updated to October 25, 2024, to identify clinical studies evaluating FAPI and [

resultsTen studies were included for qualitative assessment and five studies focusing on ovarian cancer were included in the meta-analysis. The detection rates of primary cervical cancer ranged from 96 to 100% for both radiopharmaceuticals. For the primary tumour in ovarian cancer, the pooled sensitivities of

conclusionDespite limited literature data, radiopharmaceuticals based on FAPIs are a promising alternative to [ CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Fluorodeoxyglucose F18Genital Neoplasms, FemaleRadiopharmaceuticalsFemaleHumansPositron Emission Tomography Computed TomographyFluorodeoxyglucose F18Radiopharmaceuticals[18F]FDGFAPIGynaecological cancersMeta-analysisPET/CTSystematic review

Identifiers

PMID40278857
PMCPMC12397109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.