Evidence map›Paper›PMID 40278798›Full record

Trial reportClinical transplantation2025

(Pro)renin, Erythropoietin, Vitamin D and Urodilatin Release From Human Donor Kidneys During Normothermic Machine Perfusion: Predictors of Early Post-Transplant Outcome?

Hui Lin, Karim Bousnina, Julia S Slagter, Yitian Fang, Iacopo Cristoferi, Ingrid M Garrelds, A H Jan Danser, Marlies E J Reinders, Robert C Minnee, Martin J Hoogduijn

Registry-linked trialAbstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04882254 (Normothermic Machine Perfusion as Additional Value to Hypothermic Machine Perfusion for Kidney Transplant Outcomes. A Single-centre, Open-label, Randomised, Controlled Trial.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04882254 phase2unknown statusnot on this map

Normothermic Machine Perfusion as Additional Value to Hypothermic Machine Perfusion for Kidney Transplant Outcomes. A Single-centre, Open-label, Randomised, Controlled Trial.

TypeinterventionalSponsorErasmus Medical CenterRan2021 to 2025Enrolled80ConditionsKidney Transplant Failure, Chronic Kidney FailureArmsNormothermic machine perfusion
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hui LinDepartment of Internal Medicine, Vascular Medicine and Pharmacology, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0003-2670-050X
Karim BousninaDepartment of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0009-0005-9510-9002
Julia S SlagterDepartment of Surgery, Erasmus MC Transplant Institute, division of HPB & Transplant Surgery, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-2864-1219
Yitian FangDepartment of Surgery, Erasmus MC Transplant Institute, division of HPB & Transplant Surgery, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5523-9794
Iacopo CristoferiDepartment of Surgery, Erasmus MC Transplant Institute, division of HPB & Transplant Surgery, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4282-9103
Ingrid M GarreldsDepartment of Internal Medicine, Vascular Medicine and Pharmacology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
A H Jan DanserDepartment of Internal Medicine, Vascular Medicine and Pharmacology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Marlies E J ReindersDepartment of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Robert C MinneeDepartment of Surgery, Erasmus MC Transplant Institute, division of HPB & Transplant Surgery, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Martin J HoogduijnDepartment of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Funding

Astellas Pharma, NetherlandsConvergence Health & TechnologyNierstichting
6 · The paper itself

Abstract

backgroundHuman donor kidneys release (pro)renin, erythropoietin (EPO), active vitamin D, and urodilatin during normothermic machine perfusion (NMP). However, whether the endocrine function of donor kidneys is associated with post-transplant kidney function is unclear.

methodsWe studied 28 donor kidneys, including seven from donation after brain death (DBD) donors and 21 from donation after circulatory death (DCD) donors. Prior to transplantation, we measured levels of (pro)renin, EPO, 1,25(OH)

resultsDBD kidneys secreted significantly less EPO and more active vitamin D than DCD kidneys. Kidneys with DGF exhibited significantly higher release rates of active vitamin D and lower release rates of urodilatin compared to those without DGF. In addition, EPO release rate was positively correlated with serum creatinine levels at 1-week post-transplant. Finally, urodilatin release rates were negatively correlated with DGF duration and positively correlated with urine output.

conclusionsUrodilatin release in urine and EPO and active vitamin D release in perfusate during NMP may serve as potential biomarkers for predicting early post-transplant outcomes.

trial registrationClinicalTrials.gov identifier: NCT04882254.

Indexed as

BiomarkersDelayed Graft FunctionErythropoietinKidney TransplantationPerfusionReninVitamin DAdultFemaleFollow-Up StudiesGlomerular Filtration RateGraft SurvivalHumansKidney Failure, ChronicKidney Function TestsMaleBiomarkersErythropoietinReninVitamin Ddonor kidneyearly post‐transplant outcomeendocrine functionhormone releasenormothermic machine perfusion

Identifiers

PMID40278798
PMCPMC12024645

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.