Evidence map›Paper›PMID 40278686›Full record

ArticleToxins2025

Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms.

Raechel Kadler, Breanna Morrison, Angel Anne Yanagihara

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Raechel KadlerDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0009-0000-6266-7941
Breanna MorrisonDepartment of Public Health, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-7473-2402
Angel Anne YanagiharaDepartment of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0001-6908-8176

Funding

WORLDWIDE EPIDEMIOLOGY &EPIZOOTIOLOGY OF HANTAVIRUSG12RR003061 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI PANEE, JUN · 1986 to 2011
$32.3M
UHI COBRE: SOLID STATE NMR STUDIES OF MINERALIZED ELASTINP20RR016453 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI SHOHET, RALPH V. · 2001 to 2011
$21.2M
UNIVERSITY OF HAWAII SNRPU54NS039406 · NINDS · UNIVERSITY OF HAWAII AT MANOA · PI NICHOLS, ROBERT · 1999 to 2009
$14.4M
Small Grants ProgramP30GM114737 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI NERURKAR, VIVEK RAMCHANDRA · 2015 to 2022
$8.1M
TRPV Pharmacophores from Cnidaria VenomR21DA024444 · NIDA · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, ANGEL ANNE · 2008 to 2009
$447k
Pathogenesis of Life Threatening Box Jellyfish Envenomation and Irukandji SyndromeR21ES027230 · NIEHS · UNIVERSITY OF HAWAII AT MANOA · PI YANAGIHARA, ANGEL ANNE · 2016 to 2017
$424k
NCRR NIH HHS G12 RR003061NCRR NIH HHS P20 RR016453NIDA NIH HHS R21 DA024444NIEHS NIH HHS R21 ES027230NIGMS NIH HHS P30 GM114737NINDS NIH HHS U54 NS039406
6 · The paper itself

Abstract

Examination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins. While antivenoms targeting other unique and lethal venom components have proven to be life-saving, venom-enzyme-driven tissue damage and morbidity persists. Broad-acting enzyme inhibitors demonstrate the potential to augment antivenom approaches. In this study, we investigate the potential utility of certain broad-acting inhibitors in cubozoa for the first time. Fluorogenic assays were used to determine the phospholipase A

Indexed as

Cnidarian VenomsDoxycyclineMatrix Metalloproteinase InhibitorsPhospholipase A2 InhibitorsAnimalsAntiveninsBee VenomsMatrix MetalloproteinasesPhospholipases A2ScyphozoaAntiveninsBee VenomsCnidarian VenomsDoxycyclineMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesPhospholipase A2 InhibitorsPhospholipases A2cubozoametalloproteinasephospholipasesmall-molecule inhibitorstherapeutics

Identifiers

PMID40278686
PMCPMC12031005

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.