Evidence map›Paper›PMID 40278685›Full record

ArticleToxins2025

BrnQ Branched-Chain Amino Acid Transporters Influence Toxin Production by, but Not Growth of,

Jihong Li, Iman Mehdizadeh Gohari, Isabella Zhang, Bruce A McClane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jihong LiDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Iman Mehdizadeh GohariDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Isabella ZhangDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.
Bruce A McClaneDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.ORCID 0000-0003-2451-5140

Funding

Evaluating the role of branched chain amino acid transporters in Clostridium perfringens-induced gas gangrene in diabetic and normal mouse modelsR21AI178207 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, JIHONG, MC CLANE, BRUCE A · 2023 to 2024
$427k
National Institute of Allergy and Infectious Diseases R21AI178207-02NIAID NIH HHS R21 AI178207
6 · The paper itself

Abstract

By producing alpha toxin (PLC) and perfringolysin O (PFO),

Indexed as

Amino Acids, Branched-ChainAmino Acid Transport SystemsBacterial ProteinsBacterial ToxinsClostridium perfringensType C PhospholipasesCalcium-Binding ProteinsGene Expression Regulation, Bacterialalpha toxin, Clostridium perfringensAmino Acids, Branched-ChainAmino Acid Transport SystemsBacterial ProteinsBacterial ToxinsCalcium-Binding ProteinsType C Phospholipasesalpha toxinBrnQ transportersClostridium perfringensperfringolysin Oregulation

Identifiers

PMID40278685
PMCPMC12031218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.