Evidence map›Paper›PMID 40278681›Full record

ArticleToxins2025

Insights into the Protein-Lipid Interaction of Perivitellin-2, an Unusual Snail Pore-Forming Toxin.

Romina F Vázquez, M Antonieta Daza Millone, Matías L Giglio, Tabata R Brola, Sabina M Maté, Horacio Heras

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Romina F VázquezInstituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner", INIBIOLP, CCT-La Plata, CONICET, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata 1900, Argentina.ORCID 0000-0002-8779-3503
M Antonieta Daza MilloneInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, INIFTA, CCT-La Plata, CONICET, Universidad Nacional de La Plata, Diagonal 113 y 64, La Plata 1900, Argentina.
Matías L GiglioInstituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner", INIBIOLP, CCT-La Plata, CONICET, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata 1900, Argentina.ORCID 0000-0002-6357-9772
Tabata R BrolaInstituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner", INIBIOLP, CCT-La Plata, CONICET, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata 1900, Argentina.
Sabina M MatéInstituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner", INIBIOLP, CCT-La Plata, CONICET, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata 1900, Argentina.ORCID 0000-0002-7757-1640
Horacio HerasInstituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner", INIBIOLP, CCT-La Plata, CONICET, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, La Plata 1900, Argentina.ORCID 0000-0003-3379-0216

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT 2018-02466 to MADM and PICT 2020-2779 to HH
6 · The paper itself

Abstract

The perivitellin-2 (PV2) from snails is an unusual neuro and enterotoxin comprising a pore-forming domain of the Membrane Attack Complex and Perforin Family (MACPF) linked to a lectin. While both domains have membrane binding capabilities, PV2's mechanism of action remains unclear. We studied the apple snail

Indexed as

EnterotoxinsPore Forming Cytotoxic ProteinsAnimalsBrainCell MembraneCholesterolRatsSnailsCholesterolEnterotoxinsPore Forming Cytotoxic Proteinsbrain lipidscholesterollectinlipid membranesMACPFneurotoxin/enterotoxinprotein–lipid interactionsnail pore-forming toxin

Identifiers

PMID40278681
PMCPMC12031178

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.