Evidence map›Paper›PMID 40278664›Full record

ArticleToxins2025

Ion-Channel-Targeting Scorpion Recombinant Toxin as Novel Therapeutic Agent for Breast Cancer.

Natalia Mata de Los Rios, Argel Gastelum-Arellanez, Herlinda Clement, Karely Álvarez-Cruz, Diana Romero-Terrazas, Carolina Alvarado-González, Luis Carlos Hinojos-Gallardo, Gerardo Corzo, Gerardo Pável Espino-Solis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Evaluation of the Cytotoxic Effects ofJournal of arthropod-borne diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalia Mata de Los RiosTraslational Research Laboratory, Facultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.ORCID 0009-0003-8518-5306
Argel Gastelum-ArellanezFacultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.ORCID 0000-0002-2745-6783
Herlinda ClementInstituto de Biotecnología-UNAM, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa, Cuernavaca 62210, Mexico.ORCID 0000-0001-7671-813X
Karely Álvarez-CruzTraslational Research Laboratory, Facultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.
Diana Romero-TerrazasTraslational Research Laboratory, Facultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.
Carolina Alvarado-GonzálezTraslational Research Laboratory, Facultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.ORCID 0000-0002-0308-046X
Luis Carlos Hinojos-GallardoFacultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.ORCID 0009-0000-4229-5140
Gerardo CorzoInstituto de Biotecnología-UNAM, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa, Cuernavaca 62210, Mexico.ORCID 0000-0002-9513-1622
Gerardo Pável Espino-SolisTraslational Research Laboratory, Facultad de Medicina y Ciencias Biomédicas, Autonomous University of Chihuahua, Circuito Universitario s/n, Campus II, Chihuahua 31125, Mexico.ORCID 0000-0002-9549-0676

Funding

Universidad Autonoma de Chihuahua UACH - 24-010
6 · The paper itself

Abstract

Breast cancer remains the leading cause of cancer-related mortality among women worldwide, with limited therapeutic efficacy due to treatment resistance and adverse effects. Emerging evidence suggests that ion channels play crucial roles in tumor progression, regulating proliferation, apoptosis, migration, and metastasis. Voltage-gated potassium (Kv) and sodium (Nav) channels have been implicated in oncogenic signaling pathways. Scorpion venom peptides, known for their selective ion-channel-blocking properties, have demonstrated promising antineoplastic activity. This study explores the potential therapeutic applications of bioactive fractions derived from

Indexed as

Antineoplastic AgentsBreast NeoplasmsIon ChannelsScorpion VenomsAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalFemaleHumansScorpionsAntineoplastic AgentsIon ChannelsScorpion Venomsantineoplasticbreast cancerC. coahuliaecell viabilitydoxorubicinion channelproliferation

Identifiers

PMID40278664
PMCPMC12030950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.