3,3',5,5'-Tetrabromobiphenyl (BB-80) and Its Hydroxylation Product (OH-BB-80) Mediate Immunotoxicity and Inhibit Embryonic Development in Zebrafish (

Yongjian Shao, Yinan Zhang, Xiaofang Zhang, Yu Han, Zhiquan Liu, Jiafeng Ding, Binhao Wang, Hangjun Zhang

Abstract read

In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongjian ShaoCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Yinan ZhangCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Xiaofang ZhangCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Yu HanCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Zhiquan LiuCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0003-4169-3168

Jiafeng DingCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Binhao WangCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Hangjun ZhangCollege of Engineering, Hangzhou Normal University, Hangzhou 311121, China.

Funding

Natural Science Foundation of Zhejiang Province of China LQ21B070005

6 · The paper itself

Abstract

Polybrominated biphenyls (PBBs) are metabolically transformed into monohydroxylated PBBs (OH-PBBs) in the environment and living organisms. Although OH-PBBs pose a significant health threat to organisms, little is known about the immunotoxicity of OH-PBBs. Therefore, the objectives of this study were to validate BB-80 and OH-BB-80 induced immunotoxicity and to explore the associated pathway mechanisms. Early development of zebrafish (

Indexed as

immunotoxicityinflammationoxidative stressTLR4/NF-κBzebrafish

Identifiers

PMID40278609

DOI10.3390/toxics13040293

PMCPMC12030901

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.