Evidence map›Paper›PMID 40278551›Full record

ArticleToxics2025

Semi-Correlations for the Simulation of Dermal Toxicity.

Andrey A Toropov, Alla P Toropova, Alessandra Roncaglioni, Emilio Benfenati

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrey A ToropovIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.ORCID 0000-0001-6864-6340
Alla P ToropovaIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.ORCID 0000-0002-4194-9963
Alessandra RoncaglioniIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.
Emilio BenfenatiIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.ORCID 0000-0002-3976-5989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The skin is the primary pathway for harmful substances to enter the body and a susceptible target organ, making compound-induced acute dermal toxicity a significant health risk. In this work, the possibility of modelling dermal toxicity using so-called semi-correlations is studied. Semi-correlations are a specific case of correlations, where one variable takes only two values. For example, 0 denotes the absence of activity (e.g., dermal toxicity), and 1 denotes the presence of activity. The described computational experiments can be carried out by interested readers using the freely available software CORAL.

Indexed as

acute dermal toxicityCORAL softwareMonte Carlo methodSARsemi-correlationSMILES

Identifiers

PMID40278551
PMCPMC12031574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.