Evidence map›Paper›PMID 40278547›Full record

ArticleToxics2025

CuO-NPs Induce Apoptosis and Functional Impairment in BV2 Cells Through the CSF-1R/PLCγ2/ERK/Nrf2 Pathway.

Linhui Yang, Lina Zhu, Bencheng Lin, Yue Shi, Wenqing Lai, Kang Li, Lei Tian, Zhuge Xi, Huanliang Liu

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linhui YangCollege of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China.ORCID 0009-0007-8203-451X
Lina ZhuCollege of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China.ORCID 0009-0004-3506-3084
Bencheng LinMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.
Yue ShiMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.
Wenqing LaiMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.
Kang LiMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.
Lei TianMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.
Zhuge XiMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.
Huanliang LiuMilitary Medical Sciences Academy, Academy of Military Sciences, Tianjin 300050, China.

Funding

National Natural Science Foundation of China 21407178
6 · The paper itself

Abstract

Copper oxide nanoparticles (CuO-NPs) induce neurological diseases, including neurobehavioral defects and neurodegenerative diseases. Direct evidence indicates that CuO-NPs induce inflammation in the central nervous system and cause severe neurotoxicity. However, the mechanism of CuO-NP-induced damage to the nervous system has rarely been studied, and the toxicity of different CuO-NP particle sizes and their copper ion (Cu

Indexed as

cell apoptosisCSF-1R/PLCγ2/ERK/Nrf2 pathwayCuO-NPsfunctional impairmentmicroglia

Identifiers

PMID40278547
PMCPMC12031120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.