Evidence map›Paper›PMID 40278421›Full record

ArticleNeurology international2025

Brain Structural Abnormalities in Patients with Post-COVID-19 Headache.

Klaudia Széphelyi, Szilvia Kóra, Gergely Orsi, József Tollár

Registry-linked trialAbstract read
In one paragraph

Article in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06825741 (Brain Structural Abnormalities in Patients with Post-COVID-19 Headache), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06825741 completednot on this map

Brain Structural Abnormalities in Patients with Post-COVID-19 Headache

TypeobservationalSponsorUniversity of PecsRan2020 to 2022Enrolled60ConditionsCOVID-19, Headache, MRIArmsObservational Study - No intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Klaudia SzéphelyiDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7622 Pécs, Hungary.ORCID 0000-0002-7463-7608
Szilvia KóraDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7622 Pécs, Hungary.ORCID 0009-0000-1787-3711
Gergely OrsiDepartment of Neurology, Medical School, University of Pécs, 7622 Pécs, Hungary.
József TollárDoctoral School of Health Sciences, Faculty of Health Sciences, University of Pécs, 7622 Pécs, Hungary.ORCID 0000-0001-7607-6739

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesHeadache is one of the most common neurological symptoms associated with COVID-19, affecting approximately 25% of patients. While most headaches resolve within weeks, some persist for months, suggesting underlying structural brain changes. This study aimed to identify brain MRI abnormalities associated with chronic headaches in patients with a history of COVID-19 infection.

methodsThis retrospective study included 30 patients with post-COVID-19 headaches and 30 control patients with no history of COVID-19. Demographic characteristics were analyzed using

resultsWhite matter lesions were significantly more frequent in the post-COVID-19 group (50%) compared to controls (20%) (

conclusionsPersistent post-COVID-19 headaches may be linked to structural white matter changes observed in MRI. Further research, ideally including pre-infection imaging data, is needed to determine the causal relationship between these lesions and chronic headache symptoms.

trial registrationThis study was registered in ClinicalTrials with the trial registration number NCT06825741 on 13 February 2025.

Indexed as

brainCOVID-19headacheMRIwhite matter lesion

Identifiers

PMID40278421
PMCPMC12029816

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.