Evidence map›Paper›PMID 40278359›Full record

ArticleMetabolites2025

Dietary Tea Polyphenols Alleviate Acute-Heat-Stress-Induced Death of Hybrid Crucian Carp HCC2: Involvement of Modified Lipid Metabolisms in Liver.

Na Zhang, Jinsheng Tao, Qifang Yu, Gege Sun, Xiaopeng Liu, Weirong Tang, Lina Zhang, Zhe Yang

Abstract read
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Na ZhangState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, China.
Jinsheng TaoState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, China.
Qifang YuState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, China.
Gege SunState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, China.
Xiaopeng LiuState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, China.
Weirong TangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Lina ZhangEngineering Research Center of Polyploid Fish Reproduction and Breeding of the State Education Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Zhe YangState Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, China.

Funding

Earmarked Fund for Agriculture Research System of China CARS-45National Key Research and Development Program of China 2023YFD2400202National Natural Science Foundation of China 32002382National Natural Science Foundation of China 32293252Natural Science Foundation of Hunan Province 2021JJ40339Postdoctoral Fellowship Program of CPSF GZC20230781Postdoctoral Science Foundation of Hunan Province of China 53100020001Training Program for Excellent Young Innovators of Changsha kq2209013
6 · The paper itself

Abstract

backgroundGlobal warming poses significant challenges to aquaculture, as elevated water temperatures adversely affect fish health and survival. This study investigated the effects and potential mechanisms of dietary tea polyphenols (TPs) on acute heat stress and survival in hybrid crucian carp HCC2.

methodsThe fish in the control (CON) group and heat stress group (HS group, three replicates, each containing 20 fish,

resultsNotably, dietary TPs significantly improved survival rates and antioxidant enzyme levels and reduced serum ALT, AST, cortisol, glucose, MDA, and liver HSP-70 levels in the heat-stressed fish. Metabolomic analysis revealed that TPs modulated lipid metabolism, particularly glycerophospholipid and arachidonic acid pathways, which may contribute to a higher tolerance to acute heat stress.

conclusionsThese findings suggest that TPs are a promising, eco-friendly feed additive for protecting fish from heat stress and optimizing aquaculture practices.

Indexed as

crucian carpheat stresslipid metabolismmetabolomictea polyphenols

Identifiers

PMID40278359
PMCPMC12028923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.