Evidence map›Paper›PMID 40278300›Full record

ArticleMarine drugs2025

Synthesis and Evaluation of Antitumor and Anti-Angiogenesis Activity of Pyrone- or Pyridone-Embedded Analogs of Cortistatin A.

Yuri Fujimoto, Kanako Mizuno, Yuta Nakamura, Masayoshi Arai, Naoyuki Kotoku

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuri FujimotoCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu 525-8577, Shiga, Japan.
Kanako MizunoGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Osaka, Japan.
Yuta NakamuraCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu 525-8577, Shiga, Japan.
Masayoshi AraiGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita 565-0871, Osaka, Japan.ORCID 0000-0003-2771-1948
Naoyuki KotokuCollege of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu 525-8577, Shiga, Japan.ORCID 0000-0001-7639-5553

Funding

Japan Society for the Promotion of Science 18K05363Japan Society for the Promotion of Science 22K05339the Hoanasha Foundation 2017 Special Grant
6 · The paper itself

Abstract

Simplified analogs of cortistatin A were synthesized and biologically evaluated to develop novel antitumor substances that target angiogenesis. To analyze the effect of substituents at positions corresponding to C-2 and/or C-4 of the A-ring, various pyrone- or pyridone-embedded analogs were designed and synthesized. Among the prepared analogs, the pyridone analog

Indexed as

Angiogenesis InhibitorsAntineoplastic AgentsPyridonesAnimalsCell Line, TumorHumansHuman Umbilical Vein Endothelial CellsMiceNeovascularization, PathologicNeuropeptidesStructure-Activity RelationshipXenograft Model Antitumor AssaysAngiogenesis InhibitorsAntineoplastic AgentscortistatinNeuropeptidesPyridonesanti-angiogenic substanceantitumor effectCortistatin Asimplified analog

Identifiers

PMID40278300
PMCPMC12029069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.