Evidence map›Paper›PMID 40278282›Full record

ArticleMarine drugs2025

Sustained Release of αO-Conotoxin GeXIVA[1,2] via Hydrogel Microneedle Patch for Chronic Neuropathic Pain Management.

Rongyan He, Mingjuan Li, Weitao Li, Wenqi Li, Shuting Xiao, Qiuyu Cao, Huanbai Wang, Dongting Zhangsun, Sulan Luo

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rongyan HeGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Mingjuan LiGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Weitao LiGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Wenqi LiGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Shuting XiaoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Qiuyu CaoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Huanbai WangKey Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou 570228, China.
Dongting ZhangsunGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Sulan LuoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0002-9358-5970

Funding

"Dai Tu Yi Zhi" Project of Key R & D Program of Guangxi GUIKE AA25069003Guangxi Natural Science Foundation 2025GXNSFBA069577Key Project of Natural Science Foundation of Guangxi 2024GXNSFDA999003Major Intergovernmental Joint Research Project of National Key R & D Program of China 2022YFE0132700Major International Joint Research Project of National Natural Science Foundation of China 82320108019National Natural Science Foundation of China 42376112National Natural Science Foundation of China 82360698
6 · The paper itself

Abstract

Chronic neuropathic pain severely impairs quality of life, with current therapies often causing adverse effects. Our research group identified αO-conotoxin GeXIVA[1,2] as a potent analgesic candidate derived from marine cone snails. However, its clinical application is limited by rapid clearance and complex administration. This study developed a sustained-release hydrogel microneedle patch encapsulating GeXIVA[1,2] to address these challenges. Optimized 4:3 (

Indexed as

AnalgesicsChronic PainConotoxinsNeuralgiaAdministration, CutaneousAnimalsDelayed-Action PreparationsDisease Models, AnimalDrug Delivery SystemsHydrogelsMaleMiceNeedlesPolyvinyl AlcoholTransdermal PatchAnalgesicsConotoxinsDelayed-Action PreparationsHydrogelsPolyvinyl Alcoholhydrogel encapsulationmicroneedle patchneuropathic painsustained releaseαO-conotoxin GeXIVA[1,2]

Identifiers

PMID40278282
PMCPMC12028434

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.