Evidence map›Paper›PMID 40278281›Full record

ArticleMarine drugs2025

Optimization and Preparation of Polysaccharide-Protamine Microspheres with Enhanced Hemostatic and Antibacterial Properties for Wound Healing.

Danling Mei, Feifan Cheng, Yifan Li, Suzhen Zhang, Xueqin Zhao, Yanyan Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Danling MeiCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Feifan ChengCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Yifan LiCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Suzhen ZhangCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Xueqin ZhaoCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.ORCID 0000-0002-4214-6599
Yanyan ZhaoCollege of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Funding

he China Students' Innovation and Entrepreneurship Training Program 202410338044the Fundamental Research Funds of Zhejiang Sci-Tech University 24042127-Y
6 · The paper itself

Abstract

This study employs layer-by-layer self-assembly technology to develop novel antibacterial hemostatic microspheres to tackle significant blood loss and related complications resulting from accidents, surgeries, and natural disasters. By measuring the zeta potential and particle size of protamine, carboxymethyl starch (CMS), and hydroxypropyl trimethyl ammonium chloride chitosan (HACC), the optimal assembly conditions were determined. The optimal pH for the monolayer assembly is 3.0, with a CMS concentration of 3 mg/mL and a mass ratio of 1:4 between protamine and CMS, and the assembly process lasts for 2 h. The optimal assembly conditions for the bilayer assembly are a pH of 4.0, an HACC concentration of 1 mg/mL, and a mass ratio of the one-layer assembly to HACC of 1:2. The performance of the assembled microspheres was analyzed via antibacterial and coagulation experiments, revealing excellent antibacterial and coagulation effects, with inhibition rates against

Indexed as

Anti-Bacterial AgentsHemostaticsPolysaccharidesProtaminesWound HealingAnimalsBacillus subtilisBlood CoagulationChitosanEscherichia coliHumansHydrogen-Ion ConcentrationMicrospheresParticle SizeStarchAnti-Bacterial Agentscarboxymethyl starchChitosanHemostaticsPolysaccharidesProtaminesStarchcarboxymethyl starchhydroxypropyl trimethyl ammonium chloride chitosanlayer-by-layer self-assemblyprotamine

Identifiers

PMID40278281
PMCPMC12028641

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.