Evidence map›Paper›PMID 40278272›Full record

ReviewMarine drugs2025

Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs.

Xiaofei Zhai, Xinrong Geng, Wenjun Li, Hongli Cui, Yunqing Wang, Song Qin

Abstract readReview
In one paragraph

Review in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaofei ZhaiResearch Institute of Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.
Xinrong GengResearch Institute of Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.
Wenjun LiResearch Institute of Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.
Hongli CuiYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.ORCID 0000-0002-2908-2711
Yunqing WangResearch Institute of Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.ORCID 0000-0002-2164-0766
Song QinResearch Institute of Marine Traditional Chinese Medicine (Qingdao Academy of Chinese Medical Sciences), Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.ORCID 0000-0003-3151-6889

Funding

International Partnership Program of Chinese Academy of Sciences for Grand Challenges 324GJHZ2023029GCJoint Funds of the National Natural Science Foundation of China and Shandong Province U23A20146Special Plan for Major Scientific and Technological Innovation in Qingdao West Coast ZDKC-2022-04
6 · The paper itself

Abstract

Bone tissue injuries are a significant health risk, and their repair is challenging. While various materials have potential for bone repair, issues like sourcing and immune rejection limit their use. Marine-derived collagen, abundant and free from religious and disease transmission concerns, is a promising biomaterial in bone tissue engineering. Cross-linking modification can enhance its mechanical properties and degradation rate, making it more suitable for bone repair. However, detailed analysis of cross-linking methods, property changes post-cross-linking, and their impact on bone repair is needed. This review examines marine collagen's modification methods, improved characteristics, and potential in bone tissue repair, providing a foundation for its effective use in bone tissue engineering.

Indexed as

Aquatic OrganismsBiocompatible MaterialsBone RegenerationCollagenCross-Linking ReagentsAnimalsBone and BonesHumansTissue EngineeringTissue ScaffoldsBiocompatible MaterialsCollagenCross-Linking Reagentsapplicationbone repaircross-linking modificationmarine collagen

Identifiers

PMID40278272
PMCPMC12028942

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.