Evidence map›Paper›PMID 40278266›Full record

ArticleMarine drugs2025

The Marine Compound Isaridin E Ameliorates Lipopolysaccharide-Induced Vascular Endothelial Inflammation via the Downregulation of the TLR4/NF-κB Signaling Pathway.

Jing Liu, Xin Zeng, Yu-Quan Lin, Yu-Sheng Peng, Lan Liu, Sen-Hua Chen, Yan-Hua Du

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing LiuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Xin ZengDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Yu-Quan LinDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Yu-Sheng PengDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Lan LiuSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510275, China.ORCID 0000-0003-2765-4015
Sen-Hua ChenSchool of Marine Sciences, Sun Yat-sen University, Guangzhou 510275, China.ORCID 0000-0002-5498-0206
Yan-Hua DuDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0002-7429-0456

Funding

Key R&D Program of Guangdong Province, China 2023B1111050012National Natural Science Foundation of China 82173809, 82470437
6 · The paper itself

Abstract

Isaridin E, a cyclodepsipeptide derived from the marine fungus

Indexed as

Anti-Inflammatory AgentsDepsipeptidesToll-Like Receptor 4AnimalsAquatic OrganismsCell AdhesionCytokinesDown-RegulationEndothelium, VascularEndotoxemiaFungal ProteinsHumansHuman Umbilical Vein Endothelial CellsInflammationLipopolysaccharidesMaleAnti-Inflammatory AgentsCytokinesDepsipeptidesFungal Proteinsisaridin ELipopolysaccharidesNF-kappa BPeptides, CyclicTLR4 protein, humanToll-Like Receptor 4endothelial inflammationisaridin Emarine natural productsNF-κBTLR4

Identifiers

PMID40278266
PMCPMC12028784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.