Evidence map›Paper›PMID 40278250›Full record

ArticleJournal of functional biomaterials2025

Enhanced Osteoconductivity of Zirconia Implants with One-Step Femtosecond Laser Treatment Through Morphological and Chemical Modifications.

Yuqi Li, Yanzhe Fu, Nan Li, Guanqi Liu, Jiebo Li, Jiao Wen, Jianmin Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuqi LiDepartment of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Yanzhe FuInstitute of Medical Photonics, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.ORCID 0000-0001-5519-9705
Nan LiDepartment of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Guanqi LiuDepartment of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Jiebo LiInstitute of Medical Photonics, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.ORCID 0000-0002-2295-6666
Jiao WenDepartment of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Jianmin HanDepartment of Dental Materials, Peking University School and Hospital of Stomatology, Beijing 100081, China.

Funding

Fundamental Research Funds for the Central Universities PKU2023XGK004National Key Research and Development Project Governmental International S&T Innovation Cooperation Projects 2019YFE0101100
6 · The paper itself

Abstract

Improving surface bioactivity is crucial to acquiring zirconia implants with ideal osteoconductivity. In this work, we enhanced the surface properties of zirconia implants, specifically roughness, hydrophilicity, and osteoconductivity, using a "one-step" femtosecond laser (FSL) treatment in air, deionized water, and sodium hydroxide solution. Zirconia specimens were treated in these media, and their surface morphology, chemical composition, and osteoconductivity were evaluated through various assays. The results showed that FSL treatment successfully created micro/nanoporous structures and increased roughness across all specimens. The liquid media treatment facilitated the grafting of hydroxyl (-OH) groups, significantly improving hydrophilicity. The L-NaOH group exhibited a higher hydroxyl content (28%) compared to the L-Air group (10%), reducing the contact angle significantly. Enhanced osteoblast differentiation and mineralization, along with improved gene expression, were observed in the L-Water and L-NaOH groups. In conclusion, the one-step FSL treatment developed a dual-function bioactive zirconia surface, offering an effective method for the biomedical functionalization of zirconia implants.

Indexed as

dental ceramichydroxylation“one-step” functional ablationosteogenesissurface modification

Identifiers

PMID40278250
PMCPMC12027840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.