Evidence map›Paper›PMID 40278210›Full record

ReviewJournal of cardiovascular development and disease2025

Antiplatelet and Anticoagulation Therapy in Athletes: A Cautious Compromise… If Possible!

Flavio D'Ascenzi, Guglielmo Leonardo Manfredi, Vincenzo Minasi, Gian Luca Ragazzoni, Luna Cavigli, Alessandro Zorzi, Giulia Elena Mandoli, Maria Concetta Pastore, Marta Focardi, Matteo Cameli and 2 more

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Flavio D'AscenziSports Cardiology and Rehab Unit, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0947-6836
Guglielmo Leonardo ManfrediSports Cardiology and Rehab Unit, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Vincenzo MinasiDivision of Cardiology, Policlinico Tor Vergata, University of Rome Tor Vergata, 00133 Rome, Italy.
Gian Luca RagazzoniSports Cardiology and Rehab Unit, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2915-0806
Luna CavigliSports Cardiology and Rehab Unit, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Alessandro ZorziDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, 35122 Padova, Italy.ORCID 0000-0002-3578-0583
Giulia Elena MandoliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.
Maria Concetta PastoreDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.
Marta FocardiDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-0879-8526
Matteo CameliDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.
Massimo FineschiDivision of Interventional Cardiology, University Hospital Santa Maria alle Scotte, 53100 Siena, Italy.
Serafina ValenteDepartment of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiplatelet and anticoagulation therapy are commonly used in the general population and sometimes in athletes experiencing cardiovascular disorders. In these cases, the treatment has to be tailored according to the individual bleeding and thrombotic risk profile, also considering the intrinsic risk of sports activities when advising athletes for eligibility for competitive sports. In athletes, it is necessary to pre-assess the individual bleeding risk, considering not only the personal bleeding risk (usually low in athletes) but also the type of sport the athlete would like to practice, with careful consideration in sports where traumatic collisions are highly likely. Additionally, non-steroidal anti-inflammatory drugs are commonly used among athletes, and antiplatelet therapy may further increase the bleeding risk. Therefore, in selected competitive athletes, the default approach for antithrombotic therapy could be personalized. This review discusses the clinical management challenges of competitive athletes under antithrombotic or antiplatelet therapy, focusing on the intrinsic risks of sports practice and the indications for sports eligibility and disqualification.

Indexed as

anticoagulant therapyantiplatelet therapyantithrombotic therapyathletessports cardiology

Identifiers

PMID40278210
PMCPMC12027568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.