ReviewJournal of cardiovascular development and disease2025
Pre-Workout Supplements and Their Effects on Cardiovascular Health: An Integrative Review.
Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Demystifying Nutritional Consequences of Pharmacological Weight Loss and Performance Enhancement-A Critical Narrative Review.Current obesity reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDietary supplements have become a popular aid for improving training performance. Pre-workout supplements contain a mixture of ingredients used to boost physical performance, with some components having been associated with the promotion of cardiovascular health. However, there is insufficient scientific literature on the effects of pre-workout supplements, and the studies often have conflicting results.
objectiveThe aim of this review was to analyze the impact of multi-ingredient pre-workout supplements on cardiovascular health, in order to identify the main adverse effects and the roles of the most common substances in these supplements. METHODOLOGY: A systematic search was carried out in the Web of Science and PubMed databases by three independent researchers between January 2010 and August 2024. The inclusion criteria were available articles published in English. Articles that did not evaluate cardiovascular outcomes and the use of pre-workout supplements were excluded.
resultsThe 24 studies analyzed demonstrated an overall increase in supplement intake. Pre-workout supplements were associated with improved physical performance and possible cardiovascular changes, with these effects being classified as adverse or cardioprotective. This discrepancy in the results may be due to the different dosages and populations investigated (including active and non-active participants, and healthy participants or those with a history of cardiovascular diseases), as well as other factors that correlate with deleterious cardiac conditions.
conclusionsMulti-ingredient pre-workout supplements may offer physical and cardiovascular benefits, including increased energy, focus, endurance, and strength during exercise, as well as having potential positive impacts on blood pressure and triglyceride, low-density lipoprotein (LDL), and homocysteine levels. However, due to the conflicting results of the analyzed studies, additional studies are necessary to fill in the knowledge gaps and establish clearer guidelines for the safe and effective use of these supplements.
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Registered trials
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