Evidence map›Paper›PMID 40278103›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

DNA Sequence Changes Resulting from Codon Optimization Affect Gene Expression in

Chaoyu Lu, Linna Guo, Bohao Fang, Jiacheng Shi, Mian Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Codon Usage Bias of the Polyphenol Oxidase Genes inPlants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chaoyu LuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Linna GuoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Bohao FangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.ORCID 0009-0004-7169-8810
Jiacheng ShiState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
Mian ZhouState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.ORCID 0000-0003-4226-6299

Funding

Shanghai Natural Science Foundation Program 23ZR1417600
6 · The paper itself

Abstract

Codon optimization is a widely employed strategy to enhance protein expression. However, it occasionally leads to unexpected transcriptional repression despite preserving amino acid sequences. This study investigates the mechanistic basis of such transcriptional attenuation by analyzing two gene candidates (

Indexed as

chromatin accessibilitycodon usage biasnucleosome occupancyPichia pastoris

Identifiers

PMID40278103
PMCPMC12029099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.