Evidence map›Paper›PMID 40277898›Full record

ReviewCells2025

Evolution of Allogeneic Stem Cell Transplantation: Main Focus on AML.

Yoshitaka Inoue, Joseph Cioccio, Shin Mineishi, Kentaro Minagawa

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoshitaka InoueBlood and Marrow Transplant Program, Division of Hematology and Oncology, Penn State Cancer Institute, Hershey, PA 17033, USA.ORCID 0000-0002-3967-7356
Joseph CioccioBlood and Marrow Transplant Program, Division of Hematology and Oncology, Penn State Cancer Institute, Hershey, PA 17033, USA.
Shin MineishiBlood and Marrow Transplant Program, Division of Hematology and Oncology, Penn State Cancer Institute, Hershey, PA 17033, USA.ORCID 0000-0001-7565-7080
Kentaro MinagawaBlood and Marrow Transplant Program, Division of Hematology and Oncology, Penn State Cancer Institute, Hershey, PA 17033, USA.

Funding

Arlene Witmer Memorial Fund for Bone Marrow Cancer ResearchEarl "Bumps" Clouser Memorial Lymphoma Research EndowmentG. R. Sponaugle Employee Cancer Research FundJohn and Denise Gilliland Fund for the Cancer Genetics ProgramMegan and Andrew Enders StewardshipRichard E. and Stephanie A. Ziegler Charitable Foundation Endowment in Hematology
6 · The paper itself

Abstract

In recent years, treatments in the field of hematologic malignancies have undergone significant evolution; allogeneic hematopoietic stem cell transplantation (allo-HSCT) has shifted from an "ultimate" therapy to becoming a component of a comprehensive therapeutic strategy for acute myeloid leukemia (AML). Advances in risk stratification (including molecular profiling and measurable residual disease assessment), conditioning regimens, and graft-versus-host disease (GVHD) prophylaxis-such as post-transplant cyclophosphamide-have improved outcomes and expanded donor selection and transplant eligibility. We should not only focus on the transplantation procedure but also consider various therapeutic components, including chemotherapy, targeted therapy (possibly including chimeric antigen receptor T-cell therapy), and post-transplant maintenance therapy, which need to be orchestrated within the broader context of leukemia treatment. In this review, we summarized key developments in allo-HSCT for AML and aim to "decipher" each component of transplantation.

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteGraft vs Host DiseaseHumansTransplantation ConditioningTransplantation, Homologousacute myeloid leukemia (AML)allogeneic stem cell transplantation (Allo-HSCT)GVHD prophylaxismaintenance therapymeasurable residual disease (MRD)post-transplant cyclophosphamide (PTCy)pretransplant and post-transplant strategiesTP53 mutations

Identifiers

PMID40277898
PMCPMC12026247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.