Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Nneoma C J AnyanwuDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, NY 10595-1524, USA.
Lakmini S PremadasaHost Pathogen Interaction Program, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227-5302, USA.
Wasifa NaushadDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, NY 10595-1524, USA.ORCID 0000-0002-2375-082X
Bryson C OkeomaDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, NY 10595-1524, USA.
Mahesh MohanHost Pathogen Interaction Program, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78227-5302, USA.ORCID 0000-0003-4360-3277
Chioma M OkeomaDepartment of Pathology, Microbiology, and Immunology, New York Medical College, Valhalla, NY 10595-1524, USA.ORCID 0000-0001-7737-6493
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P · 2021 to 2025
$8.3M
Role of microRNAs in B-cell dysfunction in HIV/SIV infectionR01DA042524 · NIDA · TULANE UNIVERSITY OF LOUISIANA · PI MOHAN, MAHESH · 2016 to 2020
$4.2M
Epigenetic mechanisms underlying cannabinoid modulation of neuroinflammation in HIV/SIV infection-supplementR01DA052845 · NIDA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BYRAREDDY, SIDDAPPA N, MOHAN, MAHESH · 2020 to 2024
$4.0M
Cannabinoid modulation of EV composition and function in HIV/SIV infectionR01DA050169 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOHAN, MAHESH, OKEOMA, CHIOMA M · 2019 to 2023
$3.8M
The effect of HIV and cocaine abuse on semen exosome composition and functionR01DA042348 · NIDA · UNIVERSITY OF IOWA · PI OKEOMA, CHIOMA M · 2016 to 2020
$2.7M
Characterizing the physicochemical properties of membraneless condensates and its regulation by delta-9-tetrahydrocannabinol in HIV/SIV infection.R33DA053643 · NIDA · NEW YORK MEDICAL COLLEGE · PI Mahesh Mohan, Chioma M Okeoma · 2023 to 2026
$1.3M
Characterizing the physicochemical properties of membraneless condensates and its regulation by delta-9-tetrahydrocannabinol in HIV/SIV infection.R21DA053643 · NIDA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MOHAN, MAHESH, OKEOMA, CHIOMA M · 2021 to 2022
$439k
ProteinSimple Jess System for Protein Analysis at NYMCS10OD036364 · OD · NEW YORK MEDICAL COLLEGE · PI OKEOMA, CHIOMA M · 2024 to 2024
The human gastrointestinal (GI) track host trillions of microorganisms that secrete molecules, including extracellular vesicles (EVs) and extracellular condensates (ECs) that may affect physiological and patho-physiological activities in the host. However, efficient protocols for the isolation of pure and functional GI-derived EVs|ECs is lacking. Here, we describe the use of high-resolution particle purification liquid chromatography (PPLC) gradient-bead-column integrated with polyvinylpolypyrrolidone (PVPP)-mediated extraction of impurities to isolate EVs from colonic content (ColEVs). PVPP facilitates the isolation of pure, non-toxic, and functionally active ColEVs that were internalized by cells and functionally activate HIV LTR promoter. ColEVs isolated without PVPP have a reductive effect on MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) without living cells, suggesting that ColEVs contain reductases capable of catalyzing the reduction of MTT to formazan. The assessment of the origin of ColEVs reveals that they are composed of both bacteria and host particles. This protocol requires ~12 h (5 h preprocessing, 7 h isolation) to complete and should be used to purify EVs from sources contaminated with microbial agents to improve rigor. This protocol provides a robust tool for researchers and clinicians investigating GI-derived EVs and the translational use of GI-derived EVs for diagnostic and therapeutic use. Additionally, GI-derived EVs may serve as a window into the pathogenesis of diseases.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Rigorous Process for Isolation of Gut-Derived Extracellular Vesicles (EVs) and the Effect on Latent HIV. · full record | OpenQuestion