Evidence map›Paper›PMID 40277891›Full record

ArticleCells2025

Defective Intracellular Insulin/IGF-1 Signaling Elucidates the Link Between Metabolic Defect and Autoimmunity in Vitiligo.

Silvia Caputo, Federica Papaccio, Ramona Marrapodi, Gianluca Lopez, Paolo Iacovelli, Alessia Pacifico, Emilia Migliano, Carlo Cota, Anna Di Nardo, Mauro Picardo and 1 more

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Diabetes and Vitiligo.Diabetes care · 2026
    Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvia CaputoLaboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.
Federica PapaccioLaboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.
Ramona MarrapodiLaboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.ORCID 0009-0000-6640-7418
Gianluca LopezLaboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.
Paolo IacovelliClinical Dermatology, Phototherapy Unit, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.
Alessia PacificoClinical Dermatology, Phototherapy Unit, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.
Emilia MiglianoDepartment of Plastic and Regenerative Surgery, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.ORCID 0000-0002-5316-8937
Carlo CotaGenetic Research, Molecular Biology and Dermatopathology Unit, San Gallicano Dermatological Institute, 00144 Rome, Italy.
Anna Di NardoLaboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.ORCID 0000-0002-5575-9968
Mauro PicardoIstituto Dermopatico dell'Immacolata (IDI-IRCCS), 00167 Rome, Italy.
Barbara BelleiLaboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy.ORCID 0000-0002-3883-5500

Funding

Italian Ministry of Health (MoH) PNRR-MCNT2-2023-12377707 and RC2025
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AutoimmunityInsulinInsulin-Like Growth Factor ISignal TransductionVitiligoAdultFemaleGlucoseHumansInsulin Receptor Substrate ProteinsInsulin ResistanceKeratinocytesMalePhosphorylationGlucoseInsulinInsulin-Like Growth Factor IInsulin Receptor Substrate ProteinsIGF-1inflammationinsulinmetabolismvitiligo

Identifiers

PMID40277891
PMCPMC12025416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.