Evidence map›Paper›PMID 40277794›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

Perspectives on Outpatient Delivery of Bispecific T-Cell Engager Therapies for Multiple Myeloma.

Andrée-Anne Pelland, Mathilde Dumas, Émilie Lemieux-Blanchard, Richard LeBlanc, Julie Côté, Jean-Samuel Boudreault, Dominic Duquette, Rayan Kaedbey, Marc Lalancette, Frédéric Larose and 7 more

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Andrée-Anne PellandBC Cancer, Vancouver, BC V5Z 4E6, Canada.ORCID 0009-0002-5858-6860
Mathilde DumasHôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, Canada.
Émilie Lemieux-BlanchardCentre Hospitalier de l'Université de Montréal (CHUM), Montréal, QC H2X 3E4, Canada.
Richard LeBlancHôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, Canada.ORCID 0000-0001-9990-2183
Julie CôtéCentre Hospitalier Universitaire de Québec (CHU), Québec, QC G1V 0E8, Canada.
Jean-Samuel BoudreaultHôpital du Sacré-Cœur de Montréal, Montréal, QC H4J 1C5, Canada.ORCID 0000-0003-4737-9153
Dominic DuquetteCentre Hospitalier Universitaire de Québec (CHU), Québec, QC G1V 0E8, Canada.
Rayan KaedbeyJewish General Hospital, Montréal, QC H3T 1E2, Canada.
Marc LalancetteCentre Hospitalier Universitaire de Québec (CHU), Québec, QC G1V 0E8, Canada.
Frédéric LaroseHôpital Hôtel-Dieu de Lévis, Lévis, QC G6V 3Z1, Canada.
Anna NikonovaMcGill University Health Center (CUSM), Montréal, QC H3A 0G4, Canada.ORCID 0000-0003-3255-0472
Michel PavicCentre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC J1H 5H3, Canada.ORCID 0000-0002-7057-7492
April ShamyJewish General Hospital, Montréal, QC H3T 1E2, Canada.
Jean RoyHôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, Canada.ORCID 0000-0002-7716-6864
Michael SebagMcGill University Health Center (CUSM), Montréal, QC H3A 0G4, Canada.
Sabrina TrudelHôpital Charles-Le Moyne, Greenfield Park, QC J4V 2H1, Canada.
Jean-Sébastien ClaveauHôpital Maisonneuve-Rosemont, Montréal, QC H1T 2M4, Canada.ORCID 0000-0003-2638-5773

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past few years, a new promising therapy, called bispecific T-cell engager (TCE), has been developed and is now available in many countries for patients with relapsed or refractory multiple myeloma. T-cell engagers are associated with sustained efficacy and progression-free survival benefits in patients with heavily treated myeloma. However, complications such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and infections complicate their administration, particularly in remote centers. This review discusses the key requirements for delivering TCEs therapies, focusing on outpatient delivery. We also outline the primary acute and chronic complications of TCE therapy and their management.

Indexed as

Antibodies, BispecificMultiple MyelomaT-LymphocytesHumansOutpatientsAntibodies, Bispecificbispecific antibodiesmultiple myelomatargeted immunotherapytoxicity

Identifiers

PMID40277794
PMCPMC12025952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.