Evidence map›Paper›PMID 40277781›Full record

ReviewCurrent oncology (Toronto, Ont.)2025

Modern Treatment of Skeletal Metastases: Multidisciplinarity and the Concept of Oligometastasis in the Recent Literature.

Giulia Trovarelli, Arianna Rizzo, Felicia Deborah Zinnarello, Mariachiara Cerchiaro, Andrea Angelini, Elisa Pala, Pietro Ruggieri

Abstract readReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Surgery of the tumors of the spine.EFORT open reviews · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giulia TrovarelliDepartment of Orthopedics and Orthopedic Oncology, University of Padua, 35122 Padua, Italy.
Arianna RizzoDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Felicia Deborah ZinnarelloDepartment of Orthopedics and Orthopedic Oncology, University of Padua, 35122 Padua, Italy.
Mariachiara CerchiaroDepartment of Orthopedics and Orthopedic Oncology, University of Padua, 35122 Padua, Italy.
Andrea AngeliniDepartment of Orthopedics and Orthopedic Oncology, University of Padua, 35122 Padua, Italy.ORCID 0000-0002-8823-448X
Elisa PalaDepartment of Orthopedics and Orthopedic Oncology, University of Padua, 35122 Padua, Italy.
Pietro RuggieriDepartment of Orthopedics and Orthopedic Oncology, University of Padua, 35122 Padua, Italy.ORCID 0000-0001-9617-9882

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone metastases are a major concern in cancer management since they significantly contribute to morbidity and mortality. Metastatic lesions, commonly arising from breast, prostate, lung, and kidney cancers, affect approximately 25% of cancer patients, leading to severe complications such as pain, fractures, and neurological deficits. This narrative review explores contemporary approaches to bone metastases, emphasizing a multidisciplinary strategy and the evolving concept of oligometastatic disease. Oligometastases, defined by limited metastatic spread (1-5 lesions), offer a potential window for curative treatment through aggressive interventions, including stereotactic ablative radiotherapy and resection surgery. Tumor boards, integrating systemic therapies with local interventions, are crucial to optimize treatment. Despite promising results, gaps remain in defining optimal treatment sequences and refining patient selection criteria. Future research should focus on personalized approaches, leveraging biomarkers and advanced imaging to enhance outcomes and the quality of life in patients with bone metastases.

Indexed as

Bone NeoplasmsHumansbone metastasesmultidisciplinary approacholigometastasespalliative carequality of lifesurgical treatment

Identifiers

PMID40277781
PMCPMC12025461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.