Evidence map›Paper›PMID 40277746›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Real-World Clinical Outcomes of Trilaciclib for the Prevention of Myelosuppression in Patients with Esophageal Cancer Undergoing Chemotherapy.

Hui Chen, Jingze Yan, Zeyuan Liu, Xiaolin Ge, Xinchen Sun, Xiaojie Xia

Abstract read
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hui ChenDepartment of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Jingze YanDepartment of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zeyuan LiuDepartment of Radiation Oncology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211199, China.
Xiaolin GeDepartment of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xinchen SunDepartment of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Xiaojie XiaDepartment of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Funding

the National Natural Science Foundation of China (Youth Program) 82102831the Science Foundation of Kangda College of Nanjing Medical University KD2023KYJJ265the Talent Special Fund of the First Affiliated Hospital of Nanjing Medical University YNRCQN0302
6 · The paper itself

Abstract

This study aims to evaluate the clinical effectiveness of trilaciclib in preventing myelosuppression in patients with esophageal cancer undergoing chemotherapy. Based on the use of trilaciclib, 81 patients were divided into a primary prevention group (PP group, n = 49) and a secondary prevention group (SP group, n = 32). The incidence of myelosuppression, antibiotic usage rate, survival outcomes, and other treatment-related toxicities were analyzed using chi-square tests and Kaplan-Meier survival curves. The incidence of chemotherapy-induced myelosuppression in the SP group was significantly higher than that in the PP group (96.9% vs. 79.6%), with a significantly higher proportion of grade III and above events (37.6% vs. 8.2%,

Indexed as

Antineoplastic AgentsEsophageal NeoplasmsPyrimidinesPyrrolidinesAdultAgedFemaleHumansMaleMiddle AgedNeutropeniaPyrrolesTreatment OutcomeAntineoplastic AgentsPyrimidinesPyrrolesPyrrolidinestrilaciclibesophageal cancermyelosuppressionprimary preventionsecondary preventiontrilaciclib

Identifiers

PMID40277746
PMCPMC12025781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.