Evidence map›Paper›PMID 40277721›Full record

ArticleGels (Basel, Switzerland)2025

Crystallization of Vanillin Isomers in Carboxymethyl Chitosan Gels.

Lin Zhang, Xiaoling Lu, Hao Li, Hongjie Chen, Qi Yin, Xuehan Hu, Kang Yang, Fang Yang, Liya Chen, Zeng Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lin ZhangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Xiaoling LuSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Hao LiSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Hongjie ChenSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Qi YinSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Xuehan HuSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Kang YangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Fang YangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Liya ChenSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Zeng YangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
You LongSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Chao ShenSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Bo YaoSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Chenghong HuangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.

Funding

Science and Technology Research Program of Chongqing Municipal Education Commission KJQN-202206401Science and technology training program of CQUST 202311551010,202411551008
6 · The paper itself

Abstract

The medicinal value of vanillin and its isomers has not been well developed, so it is necessary to prepare crystals of vanillin and its isomers as well as to investigate their crystallization rules in detail using advanced crystallization techniques in polymer gel. Based on molecular simulation, the maximum number of hydrogen bonds between CMCS with Van, IsoVan and oVan were reached at molar ratios of 1:9 and 1:4 and 1:5, respectively. The gel hardness and apparent viscosity of CMCS/Van isomers were proportional to the mole ratio, while elongation at break and tensile strength decreased with an increase in molar concentration depending on the position of the side chain group of the Van isomer, exposure of the benzene ring, steric resistance and the number of hydrogen bonds formed. The crystallization of Van, IsoVan and oVan in CMCS gel unexceptionally follow classical supersaturation theory in the case that nVan mainly exhibits a unique growth pattern from needle to strip, IsoVan's growth style changes from plate to bulk and oVan adapts growth pattern from needle to branch bifurcating. It was also found that the Van crystal changed from II-type to I-type under long-term heating. Studies have further confirmed that the discrepancy of physicochemical characteristics of CMCS/Van blend gel can be attributed to differences in the number of hydrogen bonds compared to CMCS with given group positions of Van isomers. This study provides powerful technical support for the gel crystallization of van isomers.

Indexed as

CMCScrystallizationvanillin isomers

Identifiers

PMID40277721
PMCPMC12027094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.