Evidence map›Paper›PMID 40277719›Full record

ArticleGels (Basel, Switzerland)2025

Three-Dimensional-Bioprinted Embedded-Based Cerebral Organoids: An Alternative Approach for Mini-Brain In Vitro Modeling Beyond Conventional Generation Methods.

Rosalba Monica Ferraro, Paola Serena Ginestra, Miriam Seiti, Mattia Bugatti, Gabriele Benini, Luana Ottelli, William Vermi, Pietro Luigi Poliani, Elisabetta Ceretti, Silvia Giliani

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Engineering brain organoids: from neurodevelopmental modeling to translational barriers.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rosalba Monica Ferraro"Angelo Nocivelli" Institute for Molecular Medicine, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Paola Serena GinestraDepartment of Mechanical and Industrial Engineering, University of Brescia, Via Branze 38, 25123 Brescia, Italy.
Miriam SeitiDepartment of Mechanical and Industrial Engineering, University of Brescia, Via Branze 38, 25123 Brescia, Italy.ORCID 0000-0002-9619-3788
Mattia BugattiASST Spedali Civili, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
Gabriele Benini"Angelo Nocivelli" Institute for Molecular Medicine, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Luana Ottelli"Angelo Nocivelli" Institute for Molecular Medicine, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
William VermiASST Spedali Civili, Piazzale Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0002-2291-2997
Pietro Luigi PolianiASST Spedali Civili, Piazzale Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0002-5662-8978
Elisabetta CerettiDepartment of Mechanical and Industrial Engineering, University of Brescia, Via Branze 38, 25123 Brescia, Italy.
Silvia Giliani"Angelo Nocivelli" Institute for Molecular Medicine, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.ORCID 0000-0001-8137-4642

Funding

European Union - Next Generation EU, Mission 4, Component 2 CUP B93D21010860004,European Union - NextGenerationEU (National Sustainable Mobility Center CN00000023, Italian Ministry of University and Research Decree n. 1033 - 17/06/2022, Spoke 11 - Innovative Materials & Lightweighting CUP: D83C22000690001
6 · The paper itself

Abstract

Cerebral organoids (cORGs) obtained from induced pluripotent stem cells (iPSCs) have become significant instruments for investigating human neurophysiology, with the possibility of simulating diseases and enhancing drug discovery. The current approaches require a strict process of manual inclusion in animal-derived matrix Matrigel

Indexed as

3D bioprintingcerebral organoidshydrogelinduced pluripotent stem cellsneural stem cellstissue engineering

Identifiers

PMID40277719
PMCPMC12027382

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.